{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:20:53Z","timestamp":1790000453033,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107\u20102221\u2010E\u2010009\u2010103"],"award-info":[{"award-number":["107\u20102221\u2010E\u2010009\u2010103"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005792","name":"University System of Taiwan","doi-asserted-by":"publisher","award":["VGHUST107\u2010G1\u20104\u20103"],"award-info":[{"award-number":["VGHUST107\u2010G1\u20104\u20103"]}],"id":[{"id":"10.13039\/501100005792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether interhemispheric functional connectivity (<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>) recovers in the first year after total callosotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight epilepsy patients undergoing total callosotomy were recruited. Resting\u2010state functional <jats:styled-content style=\"fixed-case\">magnetic resonance imaging was<\/jats:styled-content> acquired before and after surgery. The precallosotomy and postcallosotomy interhemispheric and intrahemispheric <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> was analyzed by using graph theory and voxel\u2010mirrored homotopic connectivity (<jats:styled-content style=\"fixed-case\">VMHC<\/jats:styled-content>). The seizure outcome was scored using the Engel surgical outcome scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After callosotomy (mean postoperative interval = 4\u00a0months), the network density, average node degree, characteristic path length, and global efficiency of the whole interhemispheric networks were significantly decreased, compared to those in the precallosotomy networks. However, postcallosotomy interhemispheric <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> and homotopic <jats:styled-content style=\"fixed-case\">VMHC<\/jats:styled-content> were not significantly reduced in bilateral frontal and temporal lobes. The network density and average node degree of the intrahemispheric networks were significantly increased. The characteristic path length and global efficiency of intrahemispheric networks were unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The interhemispheric <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> may be preserved or recover early within the first postoperative year after total callosotomy, particularly in the frontal and anterior temporal lobes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.14933","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T13:08:57Z","timestamp":1557839337000},"page":"1126-1136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Early recovery of interhemispheric functional connectivity after corpus callosotomy"],"prefix":"10.1111","volume":"60","author":[{"given":"Sheng\u2010Che","family":"Hung","sequence":"first","affiliation":[{"name":"Division of Neuroradiology Department of Radiology University of North Carolina School of Medicine Chapel Hill North Carolina"},{"name":"Department of Biomedical Imaging and Radiological Sciences School of Biomedical Science of Engineering National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Chia","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Neurological Institute Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Brain Research Center National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Neurological Institute Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Neurology Neurological Institute Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Mei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Radiology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Po","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Radiological Sciences School of Biomedical Science of Engineering National Yang\u2010Ming University Taipei Taiwan"},{"name":"Brain Research Center National Yang\u2010Ming University Taipei Taiwan"},{"name":"Institute of Neuroscience National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5002-6581","authenticated-orcid":false,"given":"Syu\u2010Jyun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Biomedical Electronics Translational Research Center National Chiao Tung University Hsinchu Taiwan"},{"name":"Institute of Electronics National Chiao Tung University Hsinchu Taiwan"},{"name":"Professional Master Program in Artificial Intelligence in Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13408"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060159"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121329109"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811168106"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0573-08.2008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1707050114"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3282fb8203"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21764-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025031"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3874-05.2006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi016"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2612-10.2010"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199541164.001.0001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-010-0201-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050593"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20739"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13592"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903020104"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305062110"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.11.1513"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.27.8.708"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001060"},{"key":"e_1_2_9_27_1","first-page":"1126","article-title":"Rates and predictors of seizure outcome after corpus callosotomy for drug\u2010resistant epilepsy: a meta\u2010analysis","author":"Chan AY","year":"2018","journal-title":"J Neurosurg"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003307"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1167-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2006.00615.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.14933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.14933","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.14933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T09:11:29Z","timestamp":1694337089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.14933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/epi.14933"],"URL":"https:\/\/doi.org\/10.1111\/epi.14933","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]},"assertion":[{"value":"2019-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}