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Such specificities include seizure\u2010related clinical manifestations as well as the responsiveness to antiepileptic drugs. Although increased enthusiasm accompanies the discovery of novel antibodies and their associated clinical syndromes, several issues remain unsettled. First, it appears that therapy needs to be personalized in the view of the severity of each antibody\u2010mediated syndrome, patient\u2010related characteristics, and timing of treatment. Second, the lack of randomized controlled trials is a major drawback in the formulation of an appropriate immunotherapeutic strategy. In this review, we discuss the novel developments and challenges for the diagnosis and treatment of epilepsy in patients with well\u2010characterized autoimmune encephalitis, and delineate the principles for a rational approach toward precision medicine in this emerging field.<\/jats:p>","DOI":"10.1111\/epi.16282","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T18:11:15Z","timestamp":1562609475000},"page":"1508-1525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Seizure specificities in patients with antibody\u2010mediated autoimmune encephalitis"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3652-7061","authenticated-orcid":false,"given":"Alberto","family":"Vogrig","sequence":"first","affiliation":[{"name":"French Reference Center for Paraneoplastic Neurological Syndromes Hospital for Neurology and Neurosurgery Pierre Wertheimer Lyon 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