{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:44:39Z","timestamp":1772160279924,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006117","name":"Epilepsiefonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006117","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the incidence of clinically relevant arrhythmias in refractory focal epilepsy and to assess the potential of postictal arrhythmias as risk markers for sudden unexpected death in epilepsy (SUDEP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited people with refractory focal epilepsy without signs of ictal asystole and who had at least one focal seizure per month and implanted a loop recorder with 2\u2010year follow\u2010up. The devices automatically record arrhythmias. Subjects and caregivers were instructed to make additional peri\u2010ictal recordings. Clinically relevant arrhythmias were defined as asystole \u2265 6\u00a0seconds; atrial fibrillation &lt; 55\u00a0beats per minute (bpm), or &gt; 200\u00a0bpm and duration &gt; 30\u00a0seconds; persistent sinus bradycardia &lt; 40\u00a0bpm while awake; and second\u2010 or third\u2010degree atrioventricular block and ventricular tachycardia\/fibrillation. We performed 12\u2010lead electrocardiography (ECG) and tilt table testing to identify non\u2013seizure\u2010related causes of asystole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 49 people and accumulated 1060\u00a0months of monitoring. A total of 16\u00a0474 seizures were reported, of which 4679 were captured on ECG. No clinically relevant arrhythmias were identified. Three people had a total of 18 short\u2010lasting (&lt;6\u00a0seconds) periods of asystole, resulting in an incidence of 2.91 events per 1000 patient\u2010months. None of these coincided with a reported seizure; one was explained by micturition syncope. Other non\u2013clinically relevant arrhythmias included paroxysmal atrial fibrillation (n\u00a0=\u00a02), supraventricular tachycardia (n\u00a0=\u00a01), and sinus tachycardia with a right bundle branch block configuration (n\u00a0=\u00a01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>We found no clinically relevant arrhythmias in people with refractory focal epilepsy during long\u2010term follow\u2010up. The absence of postictal arrhythmias does not support the use of loop recorders in people at high SUDEP risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.16373","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T02:13:35Z","timestamp":1571710415000},"page":"2215-2223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The yield of long\u2010term electrocardiographic recordings in refractory focal epilepsy"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4990-7212","authenticated-orcid":false,"given":"Marije","family":"van der Lende","sequence":"first","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede the Netherlands"},{"name":"Department of Neurology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan B.","family":"Arends","sequence":"additional","affiliation":[{"name":"Academic Center for Epileptology Kempenhaeghe Heeze the Netherlands"},{"name":"Signal Processing Group Electronic Engineering Faculty Technological University Eindhoven Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Lamberts","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanno L.","family":"Tan","sequence":"additional","affiliation":[{"name":"Heart Center Department of Cardiology Academic Medical Center University of Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik J.","family":"de Lange","sequence":"additional","affiliation":[{"name":"Heart Center Department of Cardiology Academic Medical Center University of Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-9661","authenticated-orcid":false,"given":"Josemir W.","family":"Sander","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede the Netherlands"},{"name":"National Institute for Health Research University College London Hospitals Biomedical Research Centre UCL Queen Square Institute of Neurology London UK"},{"name":"Chalfont Centre for Epilepsy Chalfont St Peter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud J.","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zuyderland Medical Center Heerlen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk P.","family":"Swart","sequence":"additional","affiliation":[{"name":"Department of Cardiology Antonius Hospital Sneek Sneek the 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