{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T09:44:35Z","timestamp":1786268675588,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to investigate the accident\u2010related mortality among people younger than 55\u00a0years of age with epilepsy compared with the general population and to study how psychiatric comorbidity influences this risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a population\u2010based cohort study of individuals born in Denmark between 1960 and 2015 (n\u00a0=\u00a03,\u00a0665\u00a0616). Persons diagnosed with epilepsy and psychiatric disorders were identified in the Danish National Patient Register and the Danish Central Psychiatric Central Register. We estimated the hazard ratio (HR) with 95% confidence intervals (CIs) of accidental death in people with epilepsy compared with persons without epilepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 61\u00a0330 persons (1.7%) diagnosed with epilepsy. Median age at end of follow\u2010up was 27.8\u00a0years. In people with epilepsy, 5253 died during follow\u2010up, 480 (9%) of whom died from accidents. Among people without epilepsy, 52\u00a0588 died during follow\u2010up, of whom 1280 (2.4%) died from accidents. People with epilepsy had a 3.7\u2010fold (95% CI 3.4\u20104.1) increased risk of accidental death compared with persons without epilepsy. When we adjusted for psychiatric disorders, the risk remained significantly elevated in people with epilepsy compared to people without epilepsy (adjusted HR [aHR] 2.44, 95% CI 2.22\u20102.69). When stratifying the analyses on epilepsy and psychiatric disorders, people with epilepsy and psychiatric disorders had an aHR of 4.95 (95% CI 3.82\u20106.41) when compared with persons without epilepsy and psychiatric disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The risk of accidental death was increased in people with epilepsy and was particularly high among people with epilepsy with psychiatric comorbidity. The findings highlight the need for awareness and prevention strategies in people with epilepsy, especially in people with comorbid psychiatric disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16453","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T04:53:57Z","timestamp":1582088037000},"page":"479-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Accidental deaths in young people with epilepsy and psychiatric comorbidity\u2014A Danish nationwide cohort study"],"prefix":"10.1111","volume":"61","author":[{"given":"Sissel K.","family":"Aagaard","sequence":"first","affiliation":[{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Economics and Business Economics, Business and Social Science The National Center for Register\u2010based Research Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-4170","authenticated-orcid":false,"given":"Julie W.","family":"Dreier","sequence":"additional","affiliation":[{"name":"Department of Economics and Business Economics, Business and Social Science The National Center for Register\u2010based Research Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Economics and Business Economics, Business and Social Science The National Center for Register\u2010based Research Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Laursen","sequence":"additional","affiliation":[{"name":"Department of Economics and Business Economics, Business and Social Science The National Center for Register\u2010based Research Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-6435","authenticated-orcid":false,"given":"Jakob","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Economics and Business Economics, Business and Social Science The National Center for Register\u2010based Research Aarhus University Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03121.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.00403.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2007.01.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01194.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2015.05.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.00406.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60899-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.123992"},{"key":"e_1_2_10_10_1","first-page":"263","article-title":"The Danish National Hospital Register. 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