{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:17:25Z","timestamp":1787563045109,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the potential impact of concomitant clobazam (CLB) use on the efficacy of cannabidiol (CBD) treatment in patients with Dravet syndrome and Lennox\u2010Gastaut syndrome using meta\u2010analytical techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched for randomized, placebo\u2010controlled, single\u2010 or double\u2010blinded trials. The proportion of patients who achieved \u226550% reduction from baseline in seizure frequency during the treatment period was assessed according to CLB status. Risk ratios (RRs) with 95% confidence intervals (CIs) were estimated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four trials were included and enrolled 714 participants, 429 for the add\u2010on CBD group and 285 for the add\u2010on placebo group. Among CBD\u2010treated patients, 240 (55.9%) were taking concomitant CLB (CLB\u2010On) and 189 (44.1%) were not taking concomitant CLB (CLB\u2010Off); in placebo\u2010treated patients, 158 (55.4%) were CLB\u2010On and 127 (44.6%) CLB\u2010Off. The percentages of patients who had at least 50% reduction in seizure frequency during the treatment period were 29.1% in the CBD arm and 15.7% in the placebo group among CLB\u2010Off patients (RR = 1.80, 95% CI = 1.12\u20102.90,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.015). Among CBL\u2010On patients, the \u226550% reduction in seizure frequency was found in 52.9% and 27.8% in the CBD and placebo groups, respectively (RR = 1.85, 95% CI = 1.40\u20102.44,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>CBD was associated with a higher rate of seizure response in comparison to placebo when added to the existing antiepileptic regimen both in patients taking and in those not taking concomitant CLB. The lack of randomization for CLB status and the limited sample size need to be considered in the interpretation of the findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.16546","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T07:42:53Z","timestamp":1590478973000},"page":"1090-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Cannabidiol efficacy and clobazam status: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-0083","authenticated-orcid":false,"given":"Simona","family":"Lattanzi","sequence":"first","affiliation":[{"name":"Neurological Clinic Department of Experimental and Clinical Medicine Marche Polytechnic University Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Trinka","sequence":"additional","affiliation":[{"name":"Department of Neurology Christian Doppler Clinic Paracelsus Medical University Salzburg Austria"},{"name":"Center for Cognitive Neuroscience Salzburg Austria"},{"name":"Public Health, Health Services Research, and Health Technology Assessment University for Health Sciences, Medical Informatics, and Technology Hall in Tyrol Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-1476","authenticated-orcid":false,"given":"Pasquale","family":"Striano","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Muscular Diseases Unit Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health G. Gaslini Institute University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Zaccara","sequence":"additional","affiliation":[{"name":"Health Agency of Tuscany Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Del Giovane","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care, Bernese Institute of Family Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Nardone","sequence":"additional","affiliation":[{"name":"Department of Neurology Christian Doppler Clinic Paracelsus Medical University Salzburg Austria"},{"name":"Department of Neuroscience, Biomedicine, and Movement Science University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Silvestrini","sequence":"additional","affiliation":[{"name":"Neurological Clinic Department of Experimental and Clinical Medicine Marche Polytechnic University Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-1577","authenticated-orcid":false,"given":"Francesco","family":"Brigo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine, and Movement Science University of Verona Verona Italy"},{"name":"Division of Neurology Franz Tappeiner Hospital Merano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"US Food and Drug Administration.Drug approval package: Epidiolex (cannabidiol). 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