{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:53:57Z","timestamp":1765486437935,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Innovative Medicines Initiative 2 Joint Undertaking","award":["115902"],"award-info":[{"award-number":["115902"]}]},{"name":"European Union's Horizon 2020 research and innovation programme"},{"DOI":"10.13039\/100013322","name":"EFPIA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Movement\u2010based wearable sensors are used for detection of convulsive seizures. The identification of the absence of motion following a seizure, known as post\u2010ictal immobility (PI), may represent a potential additional application of wearables. PI has been associated with potentially life\u2010threatening complications and with sudden unexpected death in epilepsy (SUDEP). We aimed to assess whether wearable accelerometers (ACCs) could be used as a digital marker of PI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Devices with embedded ACCs were worn by patients admitted to an epilepsy monitoring unit. Participants presenting with convulsive seizures were included in the study. PI presence and duration were assessed by experts reviewing video recordings. An algorithm for the automatic detection of post\u2010ictal ACC silence and its duration was developed and the linear pairwise relationship between the automatically detected duration of post\u2010ictal ACC silence and the duration of the expert\u2010labeled PI was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two convulsive seizures were recorded from 18 study participants. Twenty were followed by PI and two by agitation. The automated estimation of post\u2010ictal ACC silence identified all the 20 expert\u2010labeled PI. The regression showed that the duration of the post\u2010ictal ACC silence was correlated with the duration of PI (Pearson<jats:italic>r<\/jats:italic>\u00a0=\u00a0.92;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), with the age of study participants (Pearson<jats:italic>r<\/jats:italic>\u00a0=\u00a0.78;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and with the duration of post\u2010ictal generalized electroencephalography suppression (PGES; Pearson<jats:italic>r<\/jats:italic>\u00a0=\u00a0.4;<jats:italic>P<\/jats:italic>\u00a0=\u00a0.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We highlight a novel application of wearables as a way to record post\u2010ictal manifestations associated with an increased risk of SUDEP. The occurrence of a fatal seizure is unpredictable and the continuous, non\u2010invasive, long\u2010term identification of risk factors associated with each individual seizure may assume a great clinical importance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16552","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T12:30:19Z","timestamp":1590582619000},"page":"1397-1405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Post\u2010ictal accelerometer silence as a marker of post\u2010ictal immobility"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8166-1190","authenticated-orcid":false,"given":"Elisa","family":"Bruno","sequence":"first","affiliation":[{"name":"Division of Neuroscience Institute of Psychiatry, Psychology &amp; Neuroscience King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-8290","authenticated-orcid":false,"given":"Sebastian","family":"B\u00f6ttcher","sequence":"additional","affiliation":[{"name":"Epilepsy Center Department of Neurosurgery Medical Center University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Biondi","sequence":"additional","affiliation":[{"name":"Division of Neuroscience Institute of Psychiatry, Psychology &amp; Neuroscience King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-8286","authenticated-orcid":false,"given":"Nino","family":"Epitashvili","sequence":"additional","affiliation":[{"name":"Epilepsy Center Department of Neurosurgery Medical Center University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolay V.","family":"Manyakov","sequence":"additional","affiliation":[{"name":"Digital Phenotyping, Discovery Sciences Janssen Research &amp; Development Beerse Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Lees","sequence":"additional","affiliation":[{"name":"The RADAR\u2010CNS Patient Advisory Board King\u2019s College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schulze\u2010Bonhage","sequence":"additional","affiliation":[{"name":"Epilepsy Center Department of Neurosurgery Medical Center University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-3140","authenticated-orcid":false,"given":"Mark P.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Division of Neuroscience Institute of Psychiatry, Psychology &amp; Neuroscience King's College London London 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