{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:54:33Z","timestamp":1773744873367,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital Zika virus syndrome (CZVS) is associated with severe neurological deficits. Clinical characteristics of epilepsy and the electroencephalographic (EEG) pattern in CZVS were documented in infancy. In this study, we aimed to describe the EEG findings observed during the follow\u2010up of children with CZVS. Seventy\u2010six EEGs of 55 children (60% female; mean age = 50\u00a0months) with confirmed CZVS were analyzed, considering the background, interictal, and ictal epileptiform discharges. Continuous (or almost continuous) epileptiform discharges during non\u2013rapid eye movement sleep were identified in 22 (40%) patients. In 20 (90.1%) patients, the pattern was symmetrical, with an anterior predominance of the epileptiform activity. All patients with this pattern had epilepsy, which was severe in 15 (68.2%) and demanded polytherapy in 19 (86.4%). Subcortical calcifications (77.3%) and multifocal EEGs (72.8%) in earlier ages occurred more often in patients with this pattern. Other unspecific interictal EEG patterns were focal epileptiform discharges in 23 (41.8%) and multifocal activity in six (10.9%). In CZVS, continuous (or almost continuous) epileptiform discharges during sleep emerge as a pattern after the second year of life. This was associated with severe and drug\u2010resistant epilepsy, but not necessarily with an apparent regression. Subcortical calcifications and multifocal epileptiform discharges in infancy are associated with this pattern.<\/jats:p>","DOI":"10.1111\/epi.16631","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T12:55:00Z","timestamp":1598014500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Continuous epileptiform discharges during sleep as an evolutionary pattern in patients with congenital Zika virus syndrome"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3123-2264","authenticated-orcid":false,"suffix":"Jr","given":"H\u00e9lio","family":"van der Linden","sequence":"first","affiliation":[{"name":"Dr Henrique Santillo Rehabilitation Center Goi\u00e2nia Brazil"},{"name":"Department of Neurophysiology Neurology Institute Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"van der Linden","sequence":"additional","affiliation":[{"name":"Bar\u00e3o de Lucena Hospital Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Albert Sabin Children's Hospital Fortaleza Brazil"},{"name":"State University of Cear\u00e1 Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5008-0809","authenticated-orcid":false,"given":"Kette","family":"D. 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