{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:15:06Z","timestamp":1785500106121,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010621","name":"Pediatric Epilepsy Research Foundation","doi-asserted-by":"publisher","award":["P0522079"],"award-info":[{"award-number":["P0522079"]}],"id":[{"id":"10.13039\/100010621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["2015C2\u20101507\u201031187"],"award-info":[{"award-number":["2015C2\u20101507\u201031187"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Infantile spasms (IS) is a severe epilepsy in early childhood. Early treatment of IS provides the best chance of seizure remission and favorable developmental outcome. We aimed to develop a prediction rule to accurately predict which neonates with acute symptomatic seizures will develop IS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from the <jats:italic>Neonatal Seizure Registry<\/jats:italic>, a prospective, multicenter cohort of infants with acute symptomatic neonatal seizures born from July 2015 to March 2018. Neonates with acute symptomatic seizures who received clinical electroencephalography (EEG) and magnetic resonance imaging (MRI) and were younger than 2\u00a0years of age at the time of enrollment were included. We evaluated the association of neonatal EEG, MRI, and clinical factors with subsequent IS using bivariate analysis and best subsets logistic regression. We selected a final model through a consensus process that balanced statistical significance with clinical relevance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IS developed in 12 of 204 infants (6%). Multiple potential predictors were associated with IS, including Apgar scores, EEG features, seizure characteristics, MRI abnormalities, and clinical status at hospital discharge. The final model included three risk factors: (a) severely abnormal EEG <jats:italic>or<\/jats:italic> \u22653\u00a0days with seizures recorded on EEG, (b) deep gray <jats:italic>or<\/jats:italic> brainstem injury on MRI, and (c) abnormal tone on discharge exam. The stratified risk of IS was the following: no factors 0% (0\/82, 95% confidence interval [CI] 0%\u20104%), one or two factors 4% (4\/108, 95% CI 1%\u20109%), and all three factors 57% (8\/14, 95% CI 29%\u201083%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>IS risk after acute symptomatic neonatal seizures can be stratified using commonly available clinical data. No child without risk factors, vs &gt;50% of those with all three factors, developed IS. This risk prediction rule may be valuable for clinical counseling as well as for selecting participants for clinical trials to prevent post\u2010neonatal epilepsy. This tailored approach may lead to earlier diagnosis and treatment and improve outcomes for a devastating early life epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16749","type":"journal-article","created":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T01:58:54Z","timestamp":1605319134000},"page":"2774-2784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Risk for infantile spasms after acute symptomatic neonatal seizures"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3879-1966","authenticated-orcid":false,"given":"Hannah C.","family":"Glass","sequence":"first","affiliation":[{"name":"Department of Neurology and Weill Institute for Neurosciences University of California San Francisco San Francisco CA USA"},{"name":"Department of Pediatrics UCSF Benioff Children\u2019s Hospital University of California San Francisco San Francisco CA USA"},{"name":"Department of 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology Children\u2019s National Hospital George Washington University School of Medicine Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-9313","authenticated-orcid":false,"given":"Catherine J.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shavonne L.","family":"Massey","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics Children\u2019s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania Philadelphia PA 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