{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:23:58Z","timestamp":1782231838528,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Antiseizure medications (ASMs) can rarely result in severe, sometimes fatal, cutaneous adverse reactions. To date, few studies have reported on the incidence rates (IRs) of severe cutaneous adverse reactions (SCARs) due to ASM use. This study aimed to determine the IRs of SCAR resulting from the use of seven commonly prescribed ASMs, carbamazepine (CBZ), phenytoin (PHT), oxcarbazepine (OXC), lamotrigine (LMT), zonisamide (ZNS), levetiracetam (LVT), and topiramate (TPM), and to compare the associated risks among the drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a nationwide health claims database, we selected all the patients prescribed with one of the target ASMs. We defined a SCAR case as the first hospitalization with one of three specific codes provided by the International Classification of Diseases, 10th revision (L511, L512, and L27). We then calculated the IR of SCARs according to each target ASM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IR of SCARs for each ASM was as follows: 870\/1\u00a0000\u00a0000 person\u2010years (PYs) for CBZ, 5750\/1\u00a0000\u00a0000 PYs for PHT, 1490\/1\u00a0000\u00a0000 PYs for OXC, 3860\/1\u00a0000\u00a0000 PYs for LMT, 1540\/1\u00a0000\u00a0000 PYs for ZNS, 830\/1\u00a0000\u00a0000 PYs for LVT, and 400\/1\u00a0000\u00a0000 PYs for TPM. Concomitant use of antibiotics and nonsteroidal anti\u2010inflammatory drugs significantly increased the risk of SCARs with OXC, LVT, or TPM use. Comorbid skin disease was associated with a significantly higher IR of SCARs from CBZ, PHT, OXC, LMT, or LVT use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This is the first study in Asia to determine the IRs of SCARs for various ASMs and compare the rates across drugs using a large dataset. The results from this study should help clinicians select safer ASMs in practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16751","type":"journal-article","created":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T01:44:59Z","timestamp":1605318299000},"page":"250-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Incidence rates of severe cutaneous adverse reactions due to antiseizure medication: A nationwide study using health claims data in Korea"],"prefix":"10.1111","volume":"62","author":[{"given":"Soo Jie","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Allergy Hallym University Dongtan Sacred Heart Hospital Hallym University College of Medicine Hwaseong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Respiratory\u2010Allergy Medicine Department of Internal Medicine Soonchunhyang University College of Medicine Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Su","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ewha Womans University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6970-3228","authenticated-orcid":false,"given":"Heung\u2010Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul Korea"},{"name":"Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center Seoul Korea"},{"name":"Department of Internal Medicine Seoul National 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