{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T06:28:13Z","timestamp":1774765693057,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61871077"],"award-info":[{"award-number":["61871077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1808204"],"award-info":[{"award-number":["U1808204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871345"],"award-info":[{"award-number":["81871345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Epilepsies are a group of neurological disorders sharing certain core features, but also demonstrate remarkable pathogenic and symptomatic heterogeneities. Various subtypes of epilepsy have been identified with abnormal shift in the brain default mode network (DMN). This study aims to evaluate the fine details of shared and distinct alterations in the DMN among epileptic subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected resting\u2010state functional magnetic resonance imaging (MRI) data from a large epilepsy sample (n\u00a0=\u00a0371) at a single center, including temporal lobe epilepsy (TLE), frontal lobe epilepsy (FLE), and genetic generalized epilepsy with generalized tonic\u2010clonic seizures (GGE\u2010GTCS), as well as healthy controls (HC, n\u00a0=\u00a0150). We analyzed temporal dynamics profiling of the DMN, including edge\u2010wise and node\u2010wise temporal variabilities, and recurrent dynamic states of functional connectivity, to identify abnormalities common to epilepsies as well as those specific to each subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analyses revealed that hypervariable edges within the specific DMN subsystem were shared by all subtypes (all <jats:italic>P<\/jats:italic><jats:sub>NBS<\/jats:sub>\u00a0&lt;\u00a0.005), and deficits in node\u2010wise temporal variability were prominent in TLE (all <jats:italic>t<\/jats:italic><jats:sub>(243)<\/jats:sub> \u2264 2.51, <jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u00a0&lt;\u00a0.05) and FLE (all <jats:italic>t<\/jats:italic><jats:sub>(302)<\/jats:sub> \u2264 \u20132.65, <jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u00a0&lt;\u00a0.05) but relatively weak in GGE\u2010GTCS. Moreover, dynamic states were generally less stable in patients than controls (all <jats:italic>P<\/jats:italic>\u2019s\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Collectively, these findings demonstrated general DMN abnormalities common to different epilepsies as well as distinct dysfunctions to subtypes, and provided insights into understanding the relationship of pathophysiological mechanisms and brain connectivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16759","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T14:43:36Z","timestamp":1606315416000},"page":"61-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Temporal variability profiling of the default mode across epilepsy subtypes"],"prefix":"10.1111","volume":"62","author":[{"given":"Siqi","family":"Yang","sequence":"first","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China"},{"name":"MOE Key Lab for Neuroinformation, High\u2010Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province University of Electronic Science and Technology of China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3993-7330","authenticated-orcid":false,"given":"Zhiqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huafu","family":"Chen","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China"},{"name":"MOE Key Lab for Neuroinformation, High\u2010Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province University of Electronic Science and Technology of China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Meng","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China"},{"name":"MOE Key Lab for Neuroinformation, High\u2010Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province University of Electronic Science and Technology of China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China"},{"name":"MOE Key Lab for Neuroinformation, High\u2010Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province University of Electronic Science and Technology of China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehan","family":"Li","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China"},{"name":"MOE Key Lab for Neuroinformation, High\u2010Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province University of Electronic Science and Technology of China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Jinling Hospital Nanjing University School of Medicine Nanjing 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China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4913-2314","authenticated-orcid":false,"given":"Guangming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Jinling Hospital Nanjing University School of Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7406-7193","authenticated-orcid":false,"given":"Wei","family":"Liao","sequence":"additional","affiliation":[{"name":"The Clinical Hospital of Chengdu Brain Science Institute School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China"},{"name":"MOE Key Lab for Neuroinformation, High\u2010Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province University of Electronic Science and Technology of China Chengdu 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