{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T19:30:12Z","timestamp":1770147012504,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS108296"],"award-info":[{"award-number":["NS108296"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32 NS045540"],"award-info":[{"award-number":["T32 NS045540"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS35439"],"award-info":[{"award-number":["NS35439"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32 GM008620"],"award-info":[{"award-number":["T32 GM008620"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Prolonged fever\u2010induced seizures (febrile status epilepticus [FSE]) during early childhood increase the risk for later epilepsy, but the underlying mechanisms are incompletely understood. Experimental FSE (eFSE) in rats successfully models human FSE, recapitulating the resulting epileptogenesis in a subset of affected individuals. However, the powerful viral and genetic tools that may enhance mechanistic insights into epileptogenesis and associated comorbidities, are better\u2010developed for mice. Therefore, we aimed to determine if eFSE could be generated in mice and if it provoked enduring changes in hippocampal\u2010network excitability and the development of spontaneous seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We employed C57BL\/6J male mice, the strain used most commonly in transgenic manipulations, and examined if early life eFSE could be sustained and if it led to hyperexcitability of hippocampal networks and to epilepsy. Outcome measures included vulnerability to the subsequent administration of the limbic convulsant kainic acid (KA) and the development of spontaneous seizures. In the first mouse cohort, adult naive and eFSE\u2010experiencing mice were exposed to KA. A second cohort of control and eFSE\u2010experiencing young adult mice was implanted with bilateral hippocampal electrodes and recorded using continuous video\u2013electroencephalography (EEG) for 2 to 3\u00a0months to examine for spontaneous seizures (epileptogenesis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Induction of eFSE was feasible and eFSE increased the susceptibility of adult C57BL\/6J mice to KA, thereby reducing latency to seizure onset and increasing seizure severity. Of 24 chronically recorded eFSE mice, 4 (16.5%) developed hippocampal epilepsy with a latent period of ~3\u00a0months, significantly different from the expectation by chance (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). The limbic epilepsy that followed eFSE was progressive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>eFSE promotes pro\u2010epileptogenic network changes in a majority of C57BL\/6J male mice and frank \u201ctemporal lobe\u2013like\u201d epilepsy in one sixth of the cohort. Mouse eFSE may thus provide a useful tool for investigating molecular, cellular, and circuit changes during the development of temporal lobe epilepsy and its comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16814","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T17:59:42Z","timestamp":1611251982000},"page":"647-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Augmented seizure susceptibility and hippocampal epileptogenesis in a translational mouse model of febrile status epilepticus"],"prefix":"10.1111","volume":"62","author":[{"given":"Kevin D.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of California\u2010Irvine Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia M.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California\u2010Irvine Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3240-8310","authenticated-orcid":false,"given":"Megan M.","family":"Garcia\u2010Curran","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Neurobiology University of California\u2010Irvine Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gissell A.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California\u2010Irvine Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Daglian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California\u2010Irvine Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renhao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California\u2010Irvine Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0771-8616","authenticated-orcid":false,"given":"Tallie Z.","family":"Baram","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California\u2010Irvine Irvine CA USA"},{"name":"Department of Anatomy &amp; Neurobiology University of California\u2010Irvine Irvine CA USA"},{"name":"Department of Neurology University of California\u2010Irvine Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1996.tb00003.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198702263160901"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0263-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340604"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012078141-6\/50007-X"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(02)00083-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt233"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq251"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24081"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535759719844486"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100008246"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.07.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12451"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0551-10.2010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12061"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200003)47:3<336::AID-ANA9>3.0.CO;2-W"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0430-19.2019"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.02.042"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14561"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4806-13.2014"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3748-16.2017"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.03.040"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13420"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20358"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.078568"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep17816"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145247"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2850"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42219"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.03.026"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00003"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12697"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(96)00190-3"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/ENEURO.0034-15.2015","article-title":"Rapid, coordinate inflammatory responses after experimental febrile status epilepticus. Implications for epileptogenesis","volume":"2","author":"Patterson KP","year":"2015","journal-title":"eNeuro"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(72)90177-0"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.09.014"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2011.01.003"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00562-1"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.09.017"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.09.005"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2009.00490.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.09.064"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00571-y"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12142"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131705"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60028-z"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-020-00319-6"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13750"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-017-0103-4"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.05.003"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14440"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.178"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21931"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13180"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13088"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.16814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.16814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.16814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T09:46:23Z","timestamp":1693561583000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.16814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/epi.16814"],"URL":"https:\/\/doi.org\/10.1111\/epi.16814","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,21]]},"assertion":[{"value":"2020-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}