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In particular, the respective contribution of lesion, seizures, interictal epileptic discharges, and sleep is still debated. Here, we provide an overview of the relationships intertwining epilepsy, sleep, and memory consolidation and, based on recent findings from intracranial electroencephalographic recordings, we propose a model of ALF pathophysiology that integrates the differential role of interictal spikes during wakefulness and sleep. This model provides a framework to account for the different timescales at which ALF may occur.<\/jats:p>","DOI":"10.1111\/epi.16823","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T19:57:25Z","timestamp":1611259045000},"page":"563-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Accelerated long\u2010term forgetting in focal epilepsy: Do interictal spikes during sleep matter?"],"prefix":"10.1111","volume":"62","author":[{"given":"Isabelle","family":"Lambert","sequence":"first","affiliation":[{"name":"System Neurosciences Institute Aix Marseille University INSERM INS Marseille France"},{"name":"Epileptology and Clinical Neurophysiology Department Timone Hospital Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Tramoni\u2010Negre","sequence":"additional","affiliation":[{"name":"System Neurosciences Institute Aix Marseille 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