{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:10:18Z","timestamp":1783091418853,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001454","name":"American Epilepsy Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001454","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in patients with refractory epilepsy. The pathophysiology of SUDEP is unknown. Postictal phenomena such as postconvulsive immobility (PI), postictal generalized electroencephalography (EEG) suppression (PGES), arousal deficits, cardiac arrhythmias, central apneas, and obstructive apneas due to laryngospasms have been suggested to contribute to SUDEP. We present, to our knowledge, the first case of a near\u2010SUDEP event in a patient undergoing intracranial, stereotactic EEG (sEEG) monitoring.\u00a0This case spotlights potential mediators of SUDEP, most notably the striking PGES and postictal apnea. The nature of the sEEG investigation illustrates the extent of cortical and subcortical postictal EEG suppression and showcases a transient return of cerebral activity likely to be missed on scalp\u2010EEG recording. Critically, this case emphasizes the importance of continuous cardiorespiratory monitoring and underscores the importance of postictal arousal as a pathophysiological mechanism in SUDEP.<\/jats:p>","DOI":"10.1111\/epi.16852","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T17:10:51Z","timestamp":1614013851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Near SUDEP during bilateral stereo\u2010EEG monitoring characterized by diffuse postictal EEG suppression"],"prefix":"10.1111","volume":"62","author":[{"given":"Michael","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Neurology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niyatee","family":"Samudra","sequence":"additional","affiliation":[{"name":"Department of Neurology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-4200","authenticated-orcid":false,"given":"Martin J.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Neurology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassel","family":"Abou\u2010Khalil","sequence":"additional","affiliation":[{"name":"Department of Neurology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2318-6077","authenticated-orcid":false,"given":"William P.","family":"Nobis","sequence":"additional","affiliation":[{"name":"Department of Neurology Vanderbilt University Medical Center Nashville TN 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