{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:47:15Z","timestamp":1788540435233,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000034","name":"Institute of Neurosciences, Mental Health and Addiction","doi-asserted-by":"publisher","award":["CIHR MOP\u201057840 (AB)"],"award-info":[{"award-number":["CIHR MOP\u201057840 (AB)"]}],"id":[{"id":"10.13039\/501100000034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000034","name":"Institute of Neurosciences, Mental Health and Addiction","doi-asserted-by":"publisher","award":["CIHR MOP\u2010123520 (NB)"],"award-info":[{"award-number":["CIHR MOP\u2010123520 (NB)"]}],"id":[{"id":"10.13039\/501100000034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although temporal lobe epilepsy (TLE) is recognized as a system\u2010level disorder, little work has investigated pathoconnectomics from a dynamic perspective. By leveraging computational simulations that quantify patterns of information flow across the connectome, we tested the hypothesis that network communication is abnormal in this condition, studied the interplay between hippocampal\u2010 and network\u2010level disease effects, and assessed associations with cognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We simulated signal spreading via a linear threshold model that temporally evolves on a structural graph derived from diffusion\u2010weighted magnetic resonance imaging (MRI), comparing a homogeneous group of 31 patients with histologically proven hippocampal sclerosis to 31 age\u2010 and sex\u2010matched healthy controls. We evaluated the modulatory effects of structural alterations of the neocortex and hippocampus on network dynamics. Furthermore, multivariate statistics addressed the relationship with cognitive parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed a slowing of in\u2010 and out\u2010spreading times across multiple areas bilaterally, indexing delayed information flow, with the strongest effects in ipsilateral frontotemporal regions, thalamus, and hippocampus. Effects were markedly reduced when controlling for hippocampal volume but not cortical thickness, underscoring the central role of the hippocampus in whole\u2010brain disease expression. Multivariate analysis associated slower spreading time in frontoparietal, limbic, default mode, and subcortical networks with impairment across tasks tapping into sensorimotor, executive, memory, and verbal abilities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Moving beyond descriptions of static topology toward the formulation of brain dynamics, our work provides novel insight into structurally mediated network dysfunction and demonstrates that altered whole\u2010brain communication dynamics contribute to common cognitive difficulties in TLE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16864","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T18:39:04Z","timestamp":1615487944000},"page":"1022-1033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Altered communication dynamics reflect cognitive deficits in temporal lobe epilepsy"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9111-4905","authenticated-orcid":false,"given":"Mauricio","family":"Girardi\u2010Schappo","sequence":"first","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory McConnell Brain Imaging Center Montreal Neurological Institute and Hospital McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Fadaie","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory McConnell Brain Imaging Center Montreal Neurological Institute and Hospital McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory McConnell Brain Imaging Center Montreal Neurological Institute and Hospital McGill University Montreal QC 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C.","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Lab McConnell Brain Imaging Center Montreal Neurological Institute and Hospital McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-5703","authenticated-orcid":false,"given":"Andrea","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory McConnell Brain Imaging Center Montreal Neurological Institute and Hospital McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8947-9518","authenticated-orcid":false,"given":"Neda","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory McConnell Brain Imaging Center Montreal Neurological Institute and Hospital McGill University Montreal QC 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