{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T06:20:22Z","timestamp":1769322022776,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:00:00Z","timestamp":1615593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was undertaken to identify clinical factors associated with seizure freedom after magnetic resonance\u2010guided laser interstitial thermal therapy (MRgLiTT) in temporal lobe epilepsy patients with unilateral mesial temporal sclerosis (MTS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified 56 patients with magnetic resonance imaging\u2010defined MTS who underwent MRgLiTT with at least 1\u00a0year of follow\u2010up. Primary outcome was seizure freedom at 1 year. We examined the association of seizure freedom and the following clinical factors: age at surgery, gender, history of febrile seizures, history of focal to bilateral tonic\u2013clonic seizures, duration of epilepsy at the time of surgery, frequency of interictal epileptiform discharges (IEDs), seizure frequency, and presence of bilateral IEDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five (62.5%) patients were seizure\u2010free at 1\u00a0year. The presence of bilateral IEDs and age at surgery were associated with 1\u2010year seizure freedom after MRgLiTT. The presence of bilateral IEDS was associated with lower odds of seizure freedom (odds ratio [OR] = .05, 95% confidence interval [CI] = .01\u2013.46, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008), whereas increasing age at surgery was associated with increased odds of seizure freedom (OR = 1.10, 95% CI = 1.03\u20131.19, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study demonstrates associations between presence of bilateral IEDs and age at surgery and seizure freedom at 1\u00a0year after MRgLiTT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16872","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T17:40:00Z","timestamp":1615657200000},"page":"1085-1091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Magnetic resonance\u2010guided laser interstitial thermal therapy: Correlations with seizure outcome"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-6717","authenticated-orcid":false,"given":"Joon Y.","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Neurology Johns Hopkins School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allyson A.","family":"Pickard","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Bronder","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayane","family":"Yenokyan","sequence":"additional","affiliation":[{"name":"Johns Hopkins Biostatistics Center Department of Biostatistics Bloomberg School of Public Health Johns Hopkins University Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Hospital Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Functional Neurosurgery Department of Neurosurgery Johns Hopkins School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0708-6006","authenticated-orcid":false,"given":"Michael R.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University Hospital Philadelphia Pennsylvania 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