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PubMed\/MEDLINE, Scopus, Cochrane Library, SciELO, and LILACS were searched until June 23, 2020. Observational studies that evaluated the frequency of epilepsy in children diagnosed with CZS according to international criteria were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen studies evaluating 903 patients diagnosed with CZS were pooled in a meta\u2010analysis. All studies were conducted in Brazil, with reports published between 2016 and 2020, and included children diagnosed with CSZ from 0 to 40\u00a0months of age. The overall rate of epilepsy in children diagnosed with CZS was estimated at 60% (95% confidence interval [CI] 0.51\u20100.68). The studies included in this review show that the frequency of epilepsy in patients with CSZ varies with age, with higher rates in older children. Epileptic spasms was the primary type of seizure observed in this group, followed by focal and generalized crisis. The response rate to anti\u2010epileptic drugs was considerably low, ranging from 20% of seizure control in the first year and 30% in the second year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Children with CZS presented a high cumulative incidence of epilepsy episodes with increased severity and a low response to anti\u2010epileptic therapy, which is associated with the extensive damage caused by the Zika virus on the cortical structures of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16890","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T07:13:15Z","timestamp":1617001995000},"page":"1193-1207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Epilepsy in children with Congenital Zika Syndrome: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"62","author":[{"given":"C\u00e9sar Quadros","family":"Maia","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia M\u00e9dica Universidade Federal de S\u00e3o Jo\u00e3o del\u2010Rei, Campus Centro\u2010Oeste Dona Lindu (UFSJ\u2010CCO) Divin\u00f3polis Minas Gerais Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-9363","authenticated-orcid":false,"given":"William Gustavo","family":"Lima","sequence":"additional","affiliation":[{"name":"Researcher of the Group (CNPq) for Epidemiological, Economic and Pharmacological Studies of Arboviruses (EEPIFARBO) Divin\u00f3polis Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleska Stephanie da Cruz","family":"Nizer","sequence":"additional","affiliation":[{"name":"Carleton University Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline Maria Siqueira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia M\u00e9dica Universidade Federal de S\u00e3o Jo\u00e3o del\u2010Rei, Campus Centro\u2010Oeste Dona Lindu (UFSJ\u2010CCO) Divin\u00f3polis Minas Gerais Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2017-000530"},{"issue":"8","key":"e_1_2_10_3_1","first-page":"e69","article-title":"Zika virus replication in the mosquito Culex quinquefasciatus in Brazil","volume":"6","author":"Guedes DRD","year":"2017","journal-title":"Emerg Microbes Infect"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2016.07.002"},{"key":"e_1_2_10_5_1","unstructured":"Centers for Disease Control and Prevention.Congenital Zika Syndrome & Other Birth Defects. 2020. 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