{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:05:31Z","timestamp":1790521531895,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/07559\u20103"],"award-info":[{"award-number":["2013\/07559\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/08259\u20100"],"award-info":[{"award-number":["2019\/08259\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to better characterize the magnetic resonance imaging (MRI) findings of mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE), a rare clinicopathological entity associated with pharmacoresistance recently described in patients with frontal lobe epilepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 12 patients who underwent epilepsy surgery and whose surgical specimens showed histopathological findings of MOGHE, characterized by preserved cortical lamination, blurred gray\u2013white matter interface due to increased number of oligodendrocytes, and heterotopic neurons in the white matter. The age at MRI evaluation ranged from 11 to 58\u00a0years, except for one 4.5\u2010year\u2010old patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following a detailed MRI analysis using an in\u2010house protocol, we found abnormalities in all cases. The lesion was circumscribed in the frontal lobe in six (50%) and in the temporal lobe in three (25%) patients. In the remaining three patients (25%), the lesion was multilobar (frontotemporal and temporoparieto\u2010occipital). Cortical thickening was mild in all patients, except in the 4.5\u2010year\u2010old patient, who had pronounced cortical thickening and white matter blurring. We also identified cortical\/subcortical hyperintense T2\/fluid\u2010attenuated inversion recovery signal associated with gray\/white matter blurring in all but one patient. When present, cleft cortical dimple, and deep sulci aided in localizing the lesion. Overall, the MRI findings were like those in focal cortical dysplasia (FCD) Type IIa. Surgical outcome was excellent in five patients (Engel Class I in 25% and II in 17%). The remaining seven patients (58%) had worthwhile seizure reduction (Engle Class III). Incomplete lesion resection was significantly associated with worse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>MRI findings associated with MOGHE are similar to those described in FCD Type IIa. Although more frequent in the frontal lobe, MOGHE also occurred in the temporal lobe or involved multiple lobes. Multilobar or extensive MOGHE MRI lesions are associated with less favorable surgical outcomes. Because this is a rare condition, multicenter studies are necessary to characterize MOGHE further.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16907","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T15:56:48Z","timestamp":1619107008000},"page":"1429-1441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Magnetic resonance imaging findings and clinical characteristics in mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy in a predominantly adult cohort"],"prefix":"10.1111","volume":"62","author":[{"given":"Vanessa C.","family":"Mendes Coelho","sequence":"first","affiliation":[{"name":"Department of Neurology University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8531-3916","authenticated-orcid":false,"given":"Marcia","family":"Morita\u2010Sherman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas S\u00e3o Paulo Brazil"},{"name":"Epilepsy Center Cleveland Clinic Foundation Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-7173","authenticated-orcid":false,"given":"Clarissa L.","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6780-0761","authenticated-orcid":false,"given":"Marina M. K.","family":"Alvim","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Juarez","family":"Amorim","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Department of Radiology University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-1780","authenticated-orcid":false,"given":"Enrico","family":"Ghizoni","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-7617","authenticated-orcid":false,"given":"Fabio","family":"Rogerio","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9336-9568","authenticated-orcid":false,"given":"Fernando","family":"Cendes","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12347"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02777.x"},{"key":"e_1_2_8_4_1","volume-title":"Surgical pathology of the nervous system and its coverings","author":"Burger PC","year":"2002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1522"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"318","article-title":"Proliferative oligodendroglial hyperplasia in epilepsy (POGHE): a novel diagnostic entity","volume":"54","author":"Coras R","year":"2013","journal-title":"Epilepsia"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1684\/epd.2009.0261","article-title":"Malformations of cortical development and epilepsies: neuropathological findings with emphasis on focal cortical dysplasia","volume":"11","author":"Bl\u00fcmcke I","year":"2009","journal-title":"Epileptic Disord"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.07.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22300"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.01.028"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01085-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53486-6.00051-X"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3081"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12464"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.10.JNS12119"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.4.1148"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14140773"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.214.3.r00mr40657"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2010.0321"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1223"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws019"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03619.x"},{"key":"e_1_2_8_23_1","first-page":"1167","article-title":"(18)F\u2010FDG PET in localization of frontal lobe epilepsy: comparison of visual and SPM analysis","volume":"43","author":"Kim YK","year":"2002","journal-title":"J Nucl Med"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000334752.41807.2f"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1994.tb05989.x"},{"key":"e_1_2_8_26_1","first-page":"623","article-title":"Neuroimaging in investigation of patients with epilepsy","volume":"19","author":"Cendes F","year":"2013","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00453"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370410"},{"key":"e_1_2_8_29_1","first-page":"204","article-title":"Oligodendroglial hamartoma of the right temporal lobe: a case report and discussion of possible histogenesis","volume":"13","author":"Tasdemiroglu E","year":"1994","journal-title":"Clin Neuropathol"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16324"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.09.011"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn224"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2016.0838"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199907)46:1<88::AID-ANA13>3.0.CO;2-4"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13142"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.11.2299"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703784"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.11.008"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.16907","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.16907","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.16907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T15:21:26Z","timestamp":1698938486000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.16907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,22]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/epi.16907"],"URL":"https:\/\/doi.org\/10.1111\/epi.16907","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,22]]},"assertion":[{"value":"2020-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}