{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:27:17Z","timestamp":1784172437410,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although group studies provide some support for the material\u2010specific model of memory function, there are considerable individual variations in memory function in people with temporal lobe epilepsy, even in those with the same underlying pathology. In this proof\u2010of\u2010concept study, we examined the sensitivity and specificity of a single measure of an individual's relative strength for the encoding of verbal or visual learning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six hundred ninety\u2010two patients with left hemisphere language dominance and unilateral hippocampal sclerosis completed verbal and visual encoding tasks with similar test structures as part of their presurgical evaluation. Three hundred one patients had right hippocampal sclerosis (RHS), and 391 patients had left hippocampal sclerosis (LHS). A memory specialization index (MSI) was calculated by subtracting the Visual Learning <jats:italic>z<\/jats:italic>\u2010score from the Verbal Learning <jats:italic>z<\/jats:italic>\u2010score. A positive value on the MSI indicates a relative strength in verbal learning. A negative score indicates a relative strength in visual learning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Employing cut\u2010offs of \u00b11, the MSI had a positive predictive value of 71% (confidence interval [CI] 95% 0.64\u20130.77) for LHS and 64% (CI 95% 0.55\u20130.74) for RHS and was superior to the standalone <jats:italic>z<\/jats:italic>\u2010scores from the verbal and visual tests in each respect. In the LHS group, the MSI was significantly correlated with age and duration of epilepsy. Older patients who had a longer duration of epilepsy were more likely to demonstrate a similar level of impairment in both verbal and visual learning, with a decreasing discrepancy between the scores on the two tasks over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our MSI provides a measure with high specificity for RHS. The pattern of strengths and weaknesses in visual and verbal encoding may evolve with age and duration of epilepsy, and clinicians should be aware of these factors when interpreting the lateralizing significance of test scores, particularly in a presurgical setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16919","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T19:57:17Z","timestamp":1620676637000},"page":"1584-1593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The clinical utility of a memory specialization index in epilepsy surgery patients with unilateral hippocampal sclerosis"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9930-6469","authenticated-orcid":false,"given":"Sallie A.","family":"Baxendale","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK"},{"name":"University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Thompson","sequence":"additional","affiliation":[{"name":"University College Hospital London UK"},{"name":"Epilepsy Society Buckinghamshire 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