{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:30:47Z","timestamp":1791891047541,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD073115"],"award-info":[{"award-number":["R01HD073115"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was undertaken to examine the efficacy of a family\u2010tailored education and problem\u2010solving behavioral intervention, Supporting Treatment Adherence Regimens (STAR), in young children (2\u201312\u00a0years old) with new onset epilepsy compared to an attention control (i.e., education only [EO]) intervention. Participants randomized to the STAR intervention were hypothesized to demonstrate significantly improved adherence at postintervention and 3\u2010, 6\u2010, and 12\u2010month follow\u2010up visits compared to the EO intervention. Seizure and health\u2010related quality of life (HRQOL) outcomes were also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred children with new onset epilepsy and their caregivers were recruited during routine epilepsy clinic visits. Baseline questionnaires were completed, and electronic adherence monitors were provided. Participants with adherence less than 95% during the run\u2010in period were randomized to either STAR or EO intervention. Active intervention was provided to both groups for 4\u00a0months. Questionnaires were completed at conclusion of the active intervention phase and three follow\u2010up time points (3, 6, and 12 months). Group differences in adherence, seizure outcomes, and HRQOL were examined using regression\u2010based analyses of covariance and longitudinal mixed effect linear or logistical models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adherence at 12\u2010month follow\u2010up was significantly different between the STAR (mean\u00a0=\u00a082.34, SD\u00a0=\u00a021.29) and EO intervention groups (mean\u00a0=\u00a061.77, SD\u00a0=\u00a028.29), with the STAR group demonstrating 20.6% greater adherence (<jats:italic>b<\/jats:italic>\u00a0=\u00a019.11, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04, 95% confidence interval\u00a0=\u00a01.00\u201337.22, <jats:italic>d<\/jats:italic>\u00a0=\u00a0.83). No significant differences were found between groups in seizure and HRQOL outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>A family\u2010based behavioral adherence intervention demonstrated sustained adherence improvements 1\u00a0year following epilepsy diagnosis compared to an epilepsy\u2010specific education intervention. STAR is an efficacious adherence intervention that can easily be implemented into routine epilepsy care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16921","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T06:51:10Z","timestamp":1620888670000},"page":"1643-1655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Supporting treatment adherence regimens in children with epilepsy: A randomized clinical trial"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7580-3751","authenticated-orcid":false,"given":"Avani C.","family":"Modi","sequence":"first","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"},{"name":"College of Medicine University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanna M.","family":"Guilfoyle","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"},{"name":"College of Medicine University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy A.","family":"Glauser","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"},{"name":"College of Medicine University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance A.","family":"Mara","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"},{"name":"College of Medicine University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6631a1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000147"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001023"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12586"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.09.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12801"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01794.x"},{"key":"e_1_2_8_9_1","first-page":"CD008312","article-title":"Strategies for improving adherence to antiepileptic drug treatment in people with epilepsy","volume":"2","author":"Al\u2010Aqeel S","year":"2017","journal-title":"Cochrane Database Syst 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