{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:45:38Z","timestamp":1767861938422,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS066974"],"award-info":[{"award-number":["NS066974"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS096088"],"award-info":[{"award-number":["NS096088"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Impairment in consciousness is a debilitating symptom during and after seizures; however, its mechanism remains unclear. Limbic seizures have been shown to spread to arousal circuitry to result in a \"network inhibition\" phenomenon. However, prior animal model studies did not relate physiological network changes to behavioral responses during or following seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Focal onset limbic seizures were induced while rats were performing an operant conditioned behavioral task requiring response to an auditory stimulus to quantify how and when impairment of behavioral response occurs. Correct responses were rewarded with sucrose. Cortical and hippocampal electrophysiology measured by local field potential recordings was analyzed for changes in low\u2010 and high\u2010frequency power in relation to behavioral responsiveness during seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As seen in patients with seizures, ictal (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001) and postictal (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0015) responsiveness was variably impaired. Analysis of cortical and hippocampal electrophysiology revealed that ictal (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002) and postictal (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.009) frontal cortical low\u2010frequency 3\u20136\u2010Hz power was associated with poor behavioral performance. In contrast, the hippocampus showed increased power over a wide frequency range during seizures, and suppression postictally, neither of which were related to behavioral impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>These findings support prior human studies of temporal lobe epilepsy as well as anesthetized animal models suggesting that focal limbic seizures depress consciousness through remote network effects on the cortex, rather than through local hippocampal involvement. By identifying the cortical physiological changes associated with impaired arousal and responsiveness in focal seizures, these results may help guide future therapies to restore ictal and postictal consciousness, improving quality of life for people with epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.16964","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T10:35:36Z","timestamp":1625826936000},"page":"1960-1970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cortical low\u2010frequency power correlates with behavioral impairment in animal model of focal limbic seizures"],"prefix":"10.1111","volume":"62","author":[{"given":"Abhijeet","family":"Gummadavelli","sequence":"first","affiliation":[{"name":"Department of Neurology Yale University School of Medicine New Haven Connecticut USA"},{"name":"Department of Neurosurgery Yale University School of Medicine New Haven 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