{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:01:08Z","timestamp":1792188068485,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010621","name":"Pediatric Epilepsy Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["1507\u201031187"],"award-info":[{"award-number":["1507\u201031187"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to evaluate early\u2010life epilepsy incidence, seizure types, severity, risk factors, and treatments among survivors of acute neonatal seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Neonates with acute symptomatic seizures born 7\/2015\u20103\/2018 were prospectively enrolled at nine\n                      <jats:italic>Neonatal Seizure Registry<\/jats:italic>\n                      sites. One\u2010hour EEG was recorded at age three months. Post\u2010neonatal epilepsy and functional development (Warner Initial Developmental Evaluation of Adaptive and Functional Skills \u2013 WIDEA\u2010FS) were assessed. Cox regression was used to assess epilepsy\u2010free survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 282 infants, 37 (13%) had post\u2010neonatal epilepsy by 24\u2010months [median age of onset 7\u2010months (IQR 3\u201314)]. Among those with post\u2010neonatal epilepsy, 13\/37 (35%) had infantile spasms and 12\/37 (32%) had drug\u2010resistant epilepsy. Most children with post\u2010neonatal epilepsy had abnormal neurodevelopment at 24\u2010months (WIDEA\u2010FS &gt;2SD below normal population mean for 81% of children with epilepsy vs 27% without epilepsy, RR 7.9, 95% CI 3.6\u201317.3). Infants with severely abnormal neonatal EEG background patterns were more likely to develop epilepsy than those with mild\/moderate abnormalities (HR 3.7, 95% CI 1.9\u20135.9). Neonatal EEG with \u22653\u00a0days of seizures also predicted hazard of epilepsy (HR 2.9, 95% CI 1.4\u20135.9). In an adjusted model, days of neonatal EEG\u2010confirmed seizures (HR 1.4 per day, 95% CI 1.2\u20131.6) and abnormal discharge examination (HR 3.9, 95% CI 1.9\u20137.8) were independently associated with time to epilepsy onset. Abnormal (vs. normal) three\u2010month EEG was not associated with epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>In this multicenter study, only 13% of infants with acute symptomatic neonatal seizures developed post\u2010neonatal epilepsy by age 24\u2010months. However, there was a high risk of severe neurodevelopmental impairment and drug\u2010resistant seizures among children with post\u2010neonatal epilepsy. Days of EEG\u2010confirmed neonatal seizures was a potentially modifiable epilepsy risk factor. An EEG at three months was not clinically useful for predicting epilepsy. These practice changing findings have implications for family counseling, clinical follow\u2010up planning, and future research to prevent post\u2010neonatal epilepsy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.16978","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T05:51:30Z","timestamp":1625205090000},"page":"1871-1882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Early\u2010life epilepsy after acute symptomatic neonatal seizures: A prospective multicenter study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-3908","authenticated-orcid":false,"given":"Ren\u00e9e A.","family":"Shellhaas","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney J.","family":"Wusthoff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatal and Developmental Medicine Stanford University Palo Alto CA USA"},{"name":"Department of Neurology Stanford University Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1594-9812","authenticated-orcid":false,"given":"Adam L.","family":"Numis","sequence":"additional","affiliation":[{"name":"Department of Neurology and Weill Institute for Neuroscience University of California San Francisco San Francisco CA USA"},{"name":"Department of Pediatrics UCSF Benioff Children\u2019s Hospital University of California San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-9313","authenticated-orcid":false,"given":"Catherine J.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shavonne L.","family":"Massey","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics Children\u2019s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6166-2663","authenticated-orcid":false,"given":"Nicholas S.","family":"Abend","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics Children\u2019s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA"},{"name":"Departments of Anesthesia &amp; Critical Care Medicine Perelman School of Medicine at the University of Pennsylvania Philadelphia PA 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