{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:28Z","timestamp":1787014168967,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201011\u2010IDEX\u20100001\u201002"],"award-info":[{"award-number":["ANR\u201011\u2010IDEX\u20100001\u201002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201013\u2010PRTS\u20100011\u201001"],"award-info":[{"award-number":["ANR\u201013\u2010PRTS\u20100011\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We aimed to explore brain area(s) involved in the generation of ictal asystole (IA) by analyzing the interictal positron emission tomography (PET) metabolism of patients with IA recorded by video\u2010electroencephalography or video\u2010stereo\u2010electroencephalography. We identified in our cohort of focal epilepsy patients who had undergone presurgical evaluation those who had a recorded period of IA of more than 3 s. We investigated the anatomometabolic changes (interictal\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010fluorodeoxyglucose PET) of these patients in comparison with (1) healthy subjects with similar age and sex distribution (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a019) using whole\u2010brain voxel\u2010based analysis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010voxel &lt; .001,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010cluster &lt; .05, uncorrected) and (2) patients without IA with similar age and seizure onset zone (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a055). We found 12 patients with IA. Epilepsy was mainly temporal (four right temporal mesial, four bitemporal, two left temporal lateral, one right temporal lateral, and one right temporal \u201cplus\u201d). Seven patients had negative magnetic resonance imaging. Whole\u2010brain statistical analysis of PET imaging was performed at the voxel level, showing that in comparison to healthy subjects and to epileptic patients without IA, a hypometabolism in the right posterior insula characterized epileptic patients with IA. Our study suggests involvement of the right posterior insula\u2014a part of the central autonomic network\u2014in the pathophysiological mechanism of IA.\n                  <\/jats:p>","DOI":"10.1111\/epi.16981","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T07:12:25Z","timestamp":1625555545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Insular interictal positron emission tomography hypometabolism in patients with ictal asystole"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-1302","authenticated-orcid":false,"given":"Stanislas","family":"Lagarde","sequence":"first","affiliation":[{"name":"Aix Marseille Univ, APHM, INSERM, INS, Inst Neurosci Syst, Timone Hospital, Department of Epileptology Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinki","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology King's College Hospital London UK"},{"name":"School of Biomedical Engineering and Imaging Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-0297","authenticated-orcid":false,"given":"Fabrice","family":"Bartolomei","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, APHM, INSERM, INS, Inst Neurosci Syst, Timone Hospital, Department of Epileptology Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Guedj","sequence":"additional","affiliation":[{"name":"APHM, Timone Hospital, Department of Nuclear Medicine Marseille France"},{"name":"Aix Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel Marseille France"},{"name":"Aix Marseille Univ, CNRS, CERIMED Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)30477-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13644"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"69","article-title":"Cardiac arrhythmias during or after epileptic seizures","volume":"87","author":"Van Der Lende M","year":"2016","journal-title":"J Neurol Neurosurg 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