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Despite the best clinical judgment and currently available prediction algorithms, surgical outcomes remain variable. We aimed to build and to evaluate the performance of multidimensional Bayesian network classifiers (MBCs), a type of probabilistic graphical model, at predicting probability of seizure freedom after TLE surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical, neurophysiological, and imaging variables were collected from 231\u00a0TLE patients who underwent surgery at the University of California, San Francisco (UCSF) or the Montreal Neurological Institute (MNI) over a 15\u2010year period. Postsurgical Engel outcomes at year 1 (Y1), Y2, and Y5 were analyzed as primary end points. We trained an MBC model on combined data sets from both institutions. Bootstrap bias corrected cross\u2010validation (BBC\u2010CV) was used to evaluate the performance of the models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MBC was compared with logistic regression and Cox proportional hazards according to the area under the receiver\u2010operating characteristic curve (AUC). The MBC achieved an AUC of 0.67 at Y1, 0.72 at Y2, and 0.67 at Y5, which indicates modest performance yet superior to what has been reported in the state\u2010of\u2010the\u2010art studies to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The MBC can more precisely encode probabilistic relationships between predictors and class variables (Engel outcomes), achieving promising experimental results compared to other well\u2010known statistical methods. Multisite application of the MBC could further optimize its classification accuracy with prospective data sets. Online access to the MBC is provided, paving the way for its use as an adjunct clinical tool in aiding pre\u2010operative TLE surgical counseling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17002","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T15:49:42Z","timestamp":1626623382000},"page":"2113-2122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Patient specific prediction of temporal lobe epilepsy surgical outcomes"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-1699","authenticated-orcid":false,"given":"Marco","family":"Benjumeda","sequence":"first","affiliation":[{"name":"Computational Intelligence Group Department of Artificial Intelligence Universidad Polit\u00e9cnica de Madrid Madrid 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