{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:50:38Z","timestamp":1787237438443,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJCR1784"],"award-info":[{"award-number":["JPMJCR1784"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS064033"],"award-info":[{"award-number":["NS064033"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS089659"],"award-info":[{"award-number":["NS089659"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to build and validate a novel dynamic tractography\u2010based model for localizing interictal spike sources and visualizing monosynaptic spike propagations through the white matter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study investigated 1900\u00a0spike events recorded in 19 patients with drug\u2010resistant temporal lobe epilepsy (TLE) who underwent extraoperative intracranial electroencephalography (iEEG) and resective surgery. Twelve patients had mesial TLE (mTLE) without a magnetic resonance imaging\u2010visible mass lesion. The remaining seven had a mass lesion in the temporal lobe neocortex. We identified the leading and lagging sites, defined as those initially and subsequently (but within \u226450\u00a0ms) showing spike\u2010related augmentation of broadband iEEG activity. In each patient, we estimated the sources of 100\u00a0spike discharges using the latencies at given electrode sites and diffusion\u2010weighted imaging\u2010based streamline length measures. We determined whether the spatial relationship between the estimated spike sources and resection was associated with postoperative seizure outcomes. We generated videos presenting the spatiotemporal change of spike\u2010related fiber activation sites by estimating the propagation velocity using the streamline length and spike latency measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The spike propagation velocity from the source was 1.03\u00a0mm\/ms on average (95% confidence interval = .91\u20131.15) across 133 tracts noted in the 19 patients. The estimated spike sources in mTLE patients with International League Against Epilepsy Class 1 outcome were more likely to be in the resected area (83.9% vs. 72.3%, \u03c6\u00a0=\u00a0.137,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and in the medial temporal lobe region (80.5% vs. 72.5%, \u03c6\u00a0=\u00a0.090,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002) than those associated with the Class \u22652 outcomes. The resulting video successfully animated spike propagations, which were confined within the temporal lobe in mTLE but involved extratemporal lobe areas in lesional TLE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>We have, for the first time, provided dynamic tractography visualizing the spatiotemporal profiles of rapid propagations of interictal spikes through the white matter. Dynamic tractography has the potential to serve as a unique epilepsy biomarker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.17025","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T09:53:16Z","timestamp":1627552396000},"page":"2372-2384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Dynamic tractography\u2010based localization of spike sources and animation of spike propagations"],"prefix":"10.1111","volume":"62","author":[{"given":"Takumi","family":"Mitsuhashi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Michigan Detroit Medical Center Wayne State University Detroit Michigan USA"},{"name":"Department of Neurosurgery Juntendo University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Michigan Detroit Medical Center Wayne State University Detroit Michigan USA"},{"name":"Department of Neurosurgery Yokohama City University Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Sakakura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Michigan Detroit Medical Center Wayne State University Detroit Michigan USA"},{"name":"Department of Neurosurgery University of Tsukuba Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Won","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Michigan Detroit Medical Center Wayne State University Detroit Michigan USA"},{"name":"Department of Neurology Children's Hospital of Michigan Detroit Medical Center Wayne State University Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee F.","family":"Luat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Michigan Detroit Medical Center Wayne State University Detroit Michigan USA"},{"name":"Department of Neurology Children's Hospital of Michigan Detroit Medical Center Wayne State University Detroit Michigan USA"},{"name":"Department of Pediatrics Central Michigan University Mt. Pleasant Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Children's Hospital of Michigan Detroit Medical Center Wayne State University Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8391-4067","authenticated-orcid":false,"given":"Eishi","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Michigan Detroit Medical Center Wayne State University Detroit Michigan USA"},{"name":"Department of Neurology Children's Hospital of Michigan Detroit Medical Center Wayne State University Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009439"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250409"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.4.435"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm297"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.11.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2010.12.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.11.019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22479"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.09.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1988.60.5.1695"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90154-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr211"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116763"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.11.030"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp025"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16377"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51337"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01328.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21401"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-009-0191-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt299"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802997-8.00016-5"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.06.028"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.075"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab042"},{"issue":"2","key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1528-1157.2001.4220282.x","article-title":"ILAE Commission Report. 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