{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:20:32Z","timestamp":1790619632943,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009663","name":"University Health Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Deep brain stimulation of the anterior nuclei of thalamus (ANT\u2010DBS) is effective for reduction of seizures, but little evidence is available to guide practitioners in the practical use of this therapy. In an attempt to fill this gap, a questionnaire with 37 questions was circulated to 578\u00a0clinicians who were either engaged in clinical trials of or known users of DBS for epilepsy, with responses from 141, of whom 58.2% were epileptologists and 28.4% neurosurgeons. Multiple regions of the world were represented. The survey found that the best candidates for DBS were considered those with temporal or frontal seizures, refractory to at least two medicines. Motivations for renewing therapy upon battery depletion were reduced convulsive, impaired awareness, and severe seizures and improved quality of life. Targeting of leads mainly was by magnetic resonance imaging, sometimes with intraoperative imaging or microelectrode recording. The majority used transventricular approaches. Stimulation parameters mostly imitated the SANTE study parameters, except for initial stimulation amplitudes in the 2\u20133\u2010V or \u2010mA range, versus 5\u00a0V in the SANTE study. Stimulation intensity was most often increased or reduced, respectively, for lack of efficacy or side effects, but changes in active contacts, cycle time, and pulse duration were also employed. Mood or memory problems or paresthesias were the side effects most responsible for adjustments. Off\u2010label sites stimulated included centromedian thalamus, hippocampus, neocortex, and a few others. Several physicians used DBS in conjunction with vagus nerve stimulation or responsive neurostimulation, although our study did not track efficacy for combined use. Experienced users varied more from published parameters than did inexperienced users. In conclusion, surveys of experts can provide Class IV evidence for the most prevalent practical use of ANT\u2010DBS. We present a flowchart for one protocol combining common practices. Controlled comparisons will be needed to choose the best approach.<\/jats:p>","DOI":"10.1111\/epi.17094","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T03:01:19Z","timestamp":1635217279000},"page":"2883-2898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Experience and consensus on stimulation of the anterior nucleus of thalamus for epilepsy"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5346-0180","authenticated-orcid":false,"given":"Alfonso","family":"Fasano","sequence":"first","affiliation":[{"name":"Edmond J. Safra Program in Parkinson's Disease Morton and Gloria Shulman Movement Disorders Clinic Toronto Western Hospital University Health Network Toronto Ontario Canada"},{"name":"Division of Neurology University of Toronto Toronto Ontario Canada"},{"name":"Krembil Brain Institute Toronto Ontario Canada"},{"name":"Center for Advancing Neurotechnological Innovation to Application Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Eliashiv","sequence":"additional","affiliation":[{"name":"Department of Neurology UCLA Seizure Disorders Center David Geffen School of Medicine, University of California, Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan T.","family":"Herman","sequence":"additional","affiliation":[{"name":"Epilepsy Program Department of Neurology at Barrow Neurological Institute Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5310-5549","authenticated-orcid":false,"given":"Brian N.","family":"Lundstrom","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara","family":"Polnerow","sequence":"additional","affiliation":[{"name":"Medtronic Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimie M.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and, by courtesy, Neurology and Neurological Sciences Wu Tsai Neurosciences Institute and Bio\u2010X Institute Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Neurological Sciences and, by courtesy, Department of Neurosurgery Stanford University School of Medicine Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02536.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5698\/1535-7511-11.6.203"},{"key":"e_1_2_8_4_1","first-page":"344","article-title":"Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease","volume":"50","author":"Benabid AL","year":"1987","journal-title":"Appl Neurophysiol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20961"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.02.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.02.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2020.08.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.50858"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510295"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2015.02.016"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2020.08.028"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2020.11.012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12468"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09423-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.5.FOCUS18161"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000534"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2019.1554433"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12407"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16409"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000436078.95856.56"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyy023"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.3.FOCUS1541"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.05.036"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323343"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001334"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.02.003"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.580"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13130"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4103\/aian.AIAN_487_16","article-title":"James Wenceslaus Papez, his circuit, and emotion","volume":"20","author":"Bhattacharyya KB","year":"2017","journal-title":"Ann Indian Acad Neurol"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.12.014"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.01.022"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000206364.19772.39"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16514"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebr.2019.100344"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2016.0878"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2014.913554"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13047"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2020.230"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.26001.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.09.006"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.01304.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.6.JNS152958"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2015.08.010"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-35205-2_17"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339991"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.09.014"},{"key":"e_1_2_8_48_1","first-page":"287","article-title":"Long\u2010term anterior thalamus stimulation for intractable epilepsy","volume":"31","author":"Lim SN","year":"2008","journal-title":"Chang Gung Med J"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.01.108"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000198254.08581.6b"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2011.12.003"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01044.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502344"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyaa141"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116967"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.4103\/sni.sni_25_18"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446611"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2015.10.001"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuchi.2020.03.001"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13045"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2019.106248"},{"key":"e_1_2_8_62_1","first-page":"2631","article-title":"High\u2010frequency stimulation of anterior nucleus of thalamus desynchronizes epileptic network in humans","volume":"141","author":"Yu T","year":"2018","journal-title":"Brain"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.03.010"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.09.015"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.17094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.17094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.17094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:42:59Z","timestamp":1693201379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.17094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,26]]},"references-count":63,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/epi.17094"],"URL":"https:\/\/doi.org\/10.1111\/epi.17094","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,26]]},"assertion":[{"value":"2021-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}