{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T02:03:02Z","timestamp":1782007382752,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Management of a patient presenting with a first seizure depends on the risk of additional seizures. In clinical practice, the recurrence risk is estimated by the treating physician using the neurological examination, brain imaging, a thorough history for risk factors, and routine scalp electroencephalogram (EEG) to detect abnormal epileptiform activity. The decision to use antiseizure medication can be challenging when objective findings are missing. There is a need for new biomarkers to better diagnose epilepsy following a first seizure. Recently, an EEG\u2010based novel analytical method was reported to detect paroxysmal slowing in the cortical network of patients with epilepsy. The aim of our study is to test this method's sensitivity and specificity to predict epilepsy following a first seizure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed interictal EEGs of 70 patients admitted to the emergency department of a tertiary referral center after a first seizure. Clinical data from a follow\u2010up period of at least 18\u00a0months were available. EEGs of 30 healthy controls were also analyzed and included. For each EEG, we applied an automated algorithm to detect paroxysmal slow wave events (PSWEs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of patients presenting with a first seizure, 40% had at least one additional recurring seizure and were diagnosed with epilepsy. Sixty percent did not report additional seizures. A significantly higher occurrence of PSWEs was detected in the first interictal EEG test of those patients who were eventually diagnosed with epilepsy. Conducting the EEG test within 72\u00a0h after the first seizure significantly increased the likelihood of detecting PSWEs and the predictive value for epilepsy up to 82%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The quantification of PSWEs by an automated algorithm can predict epilepsy and help the neurologist in evaluating a patient with a first seizure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17110","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T08:38:47Z","timestamp":1636447127000},"page":"190-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Paroxysmal slow wave events predict epilepsy following a first seizure"],"prefix":"10.1111","volume":"63","author":[{"given":"Daniel","family":"Zelig","sequence":"first","affiliation":[{"name":"Departments of Physiology and Cell Biology, Cognitive, and Brain Sciences Zlotowski Center for Neuroscience Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Neurology Rabin Medical Center  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oded","family":"Shor","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Felsenstein Medical Research Center Beilinson Hospital  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Ben Dor","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Yaniv\u2010Rosenfeld","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Z.","family":"Milikovsky","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Cell Biology, Cognitive, and Brain Sciences Zlotowski Center for Neuroscience Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Ofer","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Cell Biology, Cognitive, and Brain Sciences Zlotowski Center for Neuroscience Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Imtiaz","sequence":"additional","affiliation":[{"name":"Department of Medical Neuroscience Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Medical Neuroscience Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3097-4693","authenticated-orcid":false,"given":"Felix","family":"Benninger","sequence":"additional","affiliation":[{"name":"Department of Neurology Rabin Medical Center  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Felsenstein Medical Research Center Beilinson Hospital  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"issue":"7","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"e015696","DOI":"10.1136\/bmjopen-2016-015696","article-title":"Cross\u2010sectional study of the hospital management of adult patients with a suspected seizure (EPIC2)","volume":"13","author":"Dickson JM","year":"2017","journal-title":"BMJ 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