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We used three whole\u2010brain FC measures: parcelwise connectivity matrix, mean FC, and degree of FC. We trained support vector machine models with fivefold cross\u2010validation (1) to distinguish patients from controls and (2) to lateralize the hemisphere of seizure onset in patients. We reported the regions and connections with the highest importance from each model as the common FC differences between the compared groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FC measures related to the default mode and limbic networks had higher importance relative to other networks for distinguishing epilepsy patients from controls. In lateralization models, regions related to somatosensory, visual, default mode, and basal ganglia showed higher importance. The epilepsy versus control classification model trained using a 400\u2010parcel connectivity matrix achieved a median testing accuracy of 75.6% (median area under the curve [AUC]\u00a0=\u00a0.83) in repeated independent testing. Lateralization accuracy using the 400\u2010parcel connectivity matrix reached a median accuracy of 64.0% (median AUC\u00a0=\u00a0.69).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Machine learning models revealed common FC alterations in a heterogeneous group of patients with focal epilepsies. The distribution of the most altered regions supports the hypothesis that shared functional alteration exists beyond the seizure onset zone and its epileptic network. We showed that FC measures can distinguish patients from controls, and further lateralize focal epilepsies. Future studies are needed to confirm these findings by using larger numbers of epilepsy patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17160","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T03:55:57Z","timestamp":1641354957000},"page":"629-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Common functional connectivity alterations in focal epilepsies identified by machine learning"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8751-0593","authenticated-orcid":false,"given":"Taha","family":"Gholipour","sequence":"first","affiliation":[{"name":"Department of Neurology George Washington University  Washington District of Columbia USA"},{"name":"Center for Neuroscience Children's National Hospital  Washington District of Columbia USA"},{"name":"Martinos Center for Biomedical Imaging Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3592-0985","authenticated-orcid":false,"given":"Xiaozhen","family":"You","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Children's National Hospital  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7011-5212","authenticated-orcid":false,"given":"Steven M.","family":"Stufflebeam","sequence":"additional","affiliation":[{"name":"Martinos Center for Biomedical Imaging Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1255-9341","authenticated-orcid":false,"given":"Murray","family":"Loew","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering George Washington University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8581-8906","authenticated-orcid":false,"given":"Mohamad Z.","family":"Koubeissi","sequence":"additional","affiliation":[{"name":"Department of Neurology George Washington University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-2324","authenticated-orcid":false,"given":"Victoria L.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5709-0033","authenticated-orcid":false,"given":"William D.","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Department of Neurology George Washington University  Washington District of Columbia USA"},{"name":"Center for Neuroscience Children's National Hospital  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00473"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002033420503"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13791"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03533.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz243"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000221"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102765"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02938.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0103"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-015-0514-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001068"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.04.011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16759"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03590.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13085"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00419"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16333"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0235-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(09)70884-5"},{"key":"e_1_2_9_21_1","unstructured":"CiricR AdebimpeA CieslakM RosenA SatterthwaiteTD TooleyU et al.PennBBL\/xcpEngine: compatible with fmriprep outputs of version 20.07. 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