{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T05:08:19Z","timestamp":1789276099455,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Postsurgical seizure outcome following laser interstitial thermal therapy (LiTT) for the management of drug\u2010resistant mesial temporal lobe epilepsy (MTLE) has been limited to 2\u00a0years. Furthermore, its impact on presurgical mood and anxiety disorders has not been investigated. The objectives of this study were (1) to identify seizure outcome changes over a period ranging from 18 to 81\u00a0months; (2) to investigate the seizure\u2010free rate in the last follow\u2010up year; (3) to identify the variables associated with seizure freedom; and (4) to identify the impact of LiTT on presurgical mood and anxiety disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of all patients who underwent LiTT for MTLE from 2013 to 2019 at the University of Miami Comprehensive Epilepsy Center were retrospectively reviewed. Demographic, epilepsy\u2010related, cognitive, psychiatric, and LiTT\u2010related data were compared between seizure\u2010free (Engel Class I) and non\u2010seizure\u2010free (Engel Class II\u00a0+\u00a0III\u00a0+\u00a0IV) patients. Statistical analyses included univariate and multivariate stepwise logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010eight patients (mean age = 43\u00a0\u00b1\u00a014.2\u00a0years, range = 21\u201378) were followed for a mean period of 50\u00a0\u00b1\u00a020.7\u00a0months (range = 18\u201381); 29 (60.4%) achieved an Engel Class I outcome, whereas 11 (22.9%) had one to three\u00a0seizures\/year. Seizure\u2010freedom rate decreased from 77.8% to 50% among patients with 24\u2010 and &gt;61\u2010month follow\u2010up periods, respectively. In the last follow\u2010up year, 83% of all patients were seizure\u2010free. Seizure freedom was associated with having mesial temporal sclerosis (MTS), no presurgical focal to bilateral tonic\u2013clonic seizures, and no psychopathology in the last follow\u2010up year. Presurgical mood and\/or anxiety disorder were identified in 30 patients (62.5%) and remitted after LiTT in 19 (62%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>LiTT appears to be a safe and effective surgical option for treatment\u2010resistant MTLE, particularly among patients with MTS. Remission of presurgical mood and anxiety disorders can also result from LiTT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17183","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T10:26:09Z","timestamp":1644402369000},"page":"812-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Long\u2010term seizure and psychiatric outcomes following laser ablation of mesial temporal structures"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-8034","authenticated-orcid":false,"given":"Andres M.","family":"Kanner","sequence":"first","affiliation":[{"name":"Epilepsy Division Departments of Neurology Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Treice","family":"Irving","sequence":"additional","affiliation":[{"name":"Epilepsy Division Departments of Neurology Miller 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Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naymee","family":"Velez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Detyniecki","sequence":"additional","affiliation":[{"name":"Epilepsy Division Departments of Neurology Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Melo\u2010Bicchi","sequence":"additional","affiliation":[{"name":"Epilepsy Division Departments of Neurology Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Rey","sequence":"additional","affiliation":[{"name":"Epilepsy Division Departments of Neurology Miller School of Medicine University of Miami  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