{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:14:57Z","timestamp":1789704897492,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Temporal plus epilepsy (TPE) represents a rare type of epilepsy characterized by a complex epileptogenic zone including the temporal lobe and the close neighboring structures. We investigated whether the complete resection of temporal plus epileptogenic zone as defined through stereoelectroencephalography (SEEG) might improve seizure outcome in 38 patients with TPE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inclusion criteria were as follows: epilepsy surgery performed between January 1990 and December 2001, SEEG defining a temporal plus epileptogenic zone, unilobar temporal operations (\u201ctemporal lobe epilepsy [TLE] surgery\u201d) or multilobar interventions including the temporal lobe (\u201cTPE surgery\u201d), magnetic resonance imaging either normal or showing signs of hippocampal sclerosis, and postoperative follow\u2010up of at least 12\u00a0months. For each assessment of postoperative seizure outcome, at 1, 2, 5, and 10\u00a0years, we carried out descriptive analysis and classical tests of hypothesis, namely, Pearson \u03c7<jats:sup>2<\/jats:sup>test or Fisher exact test of independence on tables of frequency for each categorical variable of interest and Student<jats:italic>t<\/jats:italic>\u2010test for each continuous variable of interest, when appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one patients underwent TPE surgery and 17 underwent TLE surgery with a follow\u2010up of 12.4\u00a0\u00b1\u00a08.16\u00a0years. In the multivariate models, there was a significant effect of the time from surgery on Engel Class IA versus IB\u2013IV outcome, with a steadily worsening trend from 5\u2010year follow\u2010up onward. TPE surgery was associated with better results than TLE surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study suggests that surgical outcome in patients with TPE can be improved by a tailored, multilobar resection and confirms that SEEG is mandatory when a TPE is suspected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17185","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T08:23:25Z","timestamp":1644913405000},"page":"769-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Surgical outcome of temporal plus epilepsy is improved by multilobar resection"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-5842","authenticated-orcid":false,"given":"Carmen","family":"Barba","sequence":"first","affiliation":[{"name":"Neuroscience Department Meyer Children's Hospital\u2013University of Florence, member of the ERN EpiCARE Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4663-8515","authenticated-orcid":false,"given":"Sylvain","family":"Rheims","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292 Lyon France"},{"name":"Department of Functional Neurology and Epileptology Hospices Civils de Lyon and University of Lyon, member of the ERN EpiCARE Lyon France"},{"name":"Lyon 1 University Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorella","family":"Minotti","sequence":"additional","affiliation":[{"name":"CHU Grenoble Alpes, Univ. Grenoble\u2010Alpes, Inserm, U1216, Grenoble Institut Neurosciences Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Grisotto","sequence":"additional","affiliation":[{"name":"Department of Statistics Computer Science G. Parenti Application University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phan","family":"Chabard\u00e8s","sequence":"additional","affiliation":[{"name":"CHU Grenoble Alpes, Univ. 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