{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:29:47Z","timestamp":1779384587086,"version":"3.53.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS109439"],"award-info":[{"award-number":["R01 NS109439"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 EB026764"],"award-info":[{"award-number":["R21 EB026764"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to use a novel magnetic resonance fingerprinting (MRF) technique to examine in vivo tissue property characteristics of periventricular nodular heterotopia (PVNH). These characteristics were further correlated with stereotactic\u2010electroencephalographic (SEEG) ictal onset findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included five patients with PVNH who had SEEG\u2010guided surgery and at least 1 year of seizure freedom or substantial seizure reduction. High\u2010resolution MRF scans were acquired at 3 T, generating three\u2010dimensional quantitative T<jats:sub>1<\/jats:sub> and T<jats:sub>2<\/jats:sub>\u00a0maps. We assessed the differences between T<jats:sub>1<\/jats:sub> and T<jats:sub>2<\/jats:sub>\u00a0values from the voxels in the nodules located in the SEEG\u2010defined seizure onset zone (SOZ) and non\u2010SOZ, on \u2010individual and group levels. Receiver operating characteristic analyses were performed to obtain the optimal classification performance. Quantification of SEEG ictal onset signals from the nodules was performed by calculating power spectrum density (PSD). The association between PSD and T<jats:sub>1<\/jats:sub>\/T<jats:sub>2<\/jats:sub>\u00a0values was further assessed at different frequency bands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individual\u2010level analysis showed T<jats:sub>1<\/jats:sub> was significantly higher in SOZ voxels than non\u2010SOZ voxels (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), with an average 73% classification accuracy. Group\u2010level analysis also showed higher T<jats:sub>1<\/jats:sub> was significantly associated with SOZ voxels (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). At the optimal cutoff (normalized T<jats:sub>1<\/jats:sub> of 1.1), a 76% accuracy for classifying SOZ nodules from non\u2010SOZ nodules was achieved. T<jats:sub>1<\/jats:sub>\u00a0values were significantly associated with ictal onset PSD at the ultraslow, \u03b8, \u03b2, \u03b3, and ripple bands (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). T<jats:sub>2<\/jats:sub>\u00a0values were significantly associated with PSD only at the ultraslow band (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Quantitative MRF measures, especially T<jats:sub>1<\/jats:sub>, can provide additional noninvasive information to separate nodules in SOZ and non\u2010SOZ. The T<jats:sub>1<\/jats:sub> and T<jats:sub>2<\/jats:sub> tissue property changes carry electrophysiological underpinnings relevant to the epilepsy, as shown by their significant positive associations with power changes during the SEEG seizure onset. The use of MRF as a supplementary noninvasive tool may improve presurgical evaluation for patients with PVNH and pharmacoresistant epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17191","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T11:46:08Z","timestamp":1648467968000},"page":"1225-1237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Using magnetic resonance fingerprinting to characterize periventricular nodular heterotopias in pharmacoresistant epilepsy"],"prefix":"10.1111","volume":"63","author":[{"given":"Joon Yul","family":"Choi","sequence":"first","affiliation":[{"name":"Charles Shor Epilepsy Center Cleveland Clinic Neurological Institute  Cleveland Ohio 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Cleveland Clinic Neurological Institute  Cleveland Ohio USA"},{"name":"Department of Neurology West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Quantitative Health Science Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Sakaie","sequence":"additional","affiliation":[{"name":"Imaging Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Jones","sequence":"additional","affiliation":[{"name":"Imaging Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroatsu","family":"Murakami","sequence":"additional","affiliation":[{"name":"Charles Shor Epilepsy Center Cleveland Clinic Neurological Institute  Cleveland Ohio 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