{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:39:02Z","timestamp":1791891542959,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>18F\u2010Fluorodeoxyglucose positron emission tomography (FDG\u2010PET) is widely used in presurgical assessment in patients with drug\u2010resistant focal epilepsy (DRE) if magnetic resonance imaging (MRI) and scalp electroencephalography (EEG) do not localize the seizure onset zone or are discordant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter, retrospective observational cohort study, we included consecutive patients with DRE who had undergone FDG\u2010PET as part of their presurgical workup. We assessed the utility of FDG\u2010PET, which was defined as contributing to the decision\u2010making process to refer for resection or intracranial EEG (iEEG) or to conclude surgery was not feasible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 951 patients in this study; 479\u00a0had temporal lobe epilepsy (TLE), 219 extratemporal epilepsy (ETLE), and 253 epilepsy of uncertain lobar origin. FDG\u2010PET showed a distinct hypometabolism in 62% and was concordant with ictal EEG in 74% in TLE and in 56% in ETLE (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). FDG\u2010PET was useful in presurgical decision\u2010making in 396 patients (47%) and most beneficial in TLE compared to ETLE (58% vs. 44%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001). Overall, FDG\u2010PET contributed to recommending resection in 78 cases (20%) and iEEG in 187 cases (47%); in 131 patients (33%), FDG\u2010PET resulted in a conclusion that resection was not feasible. In TLE, seizure\u2010freedom 1\u00a0year after surgery did not differ significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.48) between patients with negative MRI and EEG\u2010PET concordance (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030, 65%) and those with positive MRI and concordant EEG (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a046, 68%). In ETLE, half of patients with negative MRI and EEG\u2010PET concordance and three quarters with positive MRI and concordant EEG were seizure\u2010free postsurgery (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05 vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.28).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This is the largest reported cohort of patients with DRE who received presurgical FDG\u2010PET, showing that FDG\u2010PET is a useful diagnostic tool. MRI\u2010negative and MRI\u2010positive cases with concordant FDG\u2010PET results (with either EEG or MRI) had a comparable outcome after surgery. These findings confirm the significance of FDG\u2010PET in presurgical epilepsy diagnostics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.17194","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T06:16:24Z","timestamp":1644905784000},"page":"1238-1252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Utility of 18F\u2010fluorodeoxyglucose positron emission tomography in presurgical evaluation of patients with epilepsy: A multicenter study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-4709","authenticated-orcid":false,"given":"Mirja","family":"Steinbrenner","sequence":"first","affiliation":[{"name":"Department of Neurology and Experimental Neurology Epilepsy Center Berlin\u2010Brandenburg Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Clinical and Experimental Epilepsy National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1373-0681","authenticated-orcid":false,"given":"John S.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1793-3822","authenticated-orcid":false,"given":"John","family":"Dickson","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine University College London Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5567-1715","authenticated-orcid":false,"given":"Chaturbhuj","family":"Rathore","sequence":"additional","affiliation":[{"name":"Department of Neurology Smt. B. K. Shah (SBKS) Medical College Sumandeep Vidyapeeth  Vadodara India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"W\u00e4chter","sequence":"additional","affiliation":[{"name":"Epilepsy Center Berlin\u2010Brandenburg Evangelische Krankenhaus K\u00f6nigin Elisabeth Herzberge  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafi","family":"Aygun","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Sciences Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramshekhar N.","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Neurology Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8564-8436","authenticated-orcid":false,"given":"Ashalatha","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Neurology Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-1670","authenticated-orcid":false,"given":"Martin","family":"Holtkamp","sequence":"additional","affiliation":[{"name":"Department of Neurology and Experimental Neurology Epilepsy Center 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