{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:14:17Z","timestamp":1789978457251,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS094743"],"award-info":[{"award-number":["R01NS094743"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Hippocampal dentation (HD) is a \u201ctoothlike\u201d morphological feature observed on the inferior aspect of the human hippocampus. It has been found that HD varies dramatically in healthy adults and is positively associated with verbal and visual memory. In this work, we evaluate the loss of HD and its association with memory dysfunction in patients with temporal lobe epilepsy (TLE) who have hippocampal sclerosis (HS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010eight unilateral HS patients with neuropsychological data were identified from a retrospective database. T1\u2010weighted magnetization\u2010prepared rapid acquisition gradient echo images (~1\u00a0mm resolution) were upsampled to .25\u00a0mm and were processed using ASHS software to obtain ultra\u2010high\u2010resolution segmentations and three\u2010dimensional renderings. Dentes were counted on the epileptic and contralateral sides, and associations were tested between dentation on the epileptic versus contralateral sides and measures of verbal and visuospatial memory with respect to the dominant versus nondominant hemisphere.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median number of dentes in epileptic hippocampi was significantly lower than in contralateral hippocampi (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001). Among cases with HS in the dominant hemisphere, verbal memory was significantly correlated with contralateral nondominant hemisphere dentation (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.43, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). Similarly, among cases of HS in the nondominant hemisphere, visual memory was significantly correlated with contralateral dominant hemisphere dentation (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.48, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). All other analyses were not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This is the first study characterizing dentation in TLE patients with HS and its memory correlates. There is marked loss of dentation in sclerotic hippocampi compared to the unaffected contralateral hippocampi. Material\u2010specific measures of memory performance are paradoxically correlated with dentation contralateral to the side with HS, suggesting that contralateral functional capacity explains some of the variation in memory across TLE patients. HD is an important variable to consider in understanding memory loss in TLE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17211","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T08:53:58Z","timestamp":1646384038000},"page":"1104-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Loss of hippocampal dentation in hippocampal sclerosis and its relationship to memory dysfunction"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-4612","authenticated-orcid":false,"given":"Anandh","family":"Kilpattu Ramaniharan","sequence":"first","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike Weng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Baptist Health Medical Group  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goutham","family":"Selladurai","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-550X","authenticated-orcid":false,"given":"Lawrence","family":"Ver Hoef","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Neurology Service Birmingham VA Medical Center  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.12.1869"},{"key":"e_1_2_9_3_1","first-page":"753","article-title":"Optimizing the diagnosis of hippocampal sclerosis using MR imaging","volume":"14","author":"Jackson GD","year":"1993","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(95)02016-M"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2154"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.2.265"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2012.00583.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0187-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh599"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22722"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00131"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101651"},{"key":"e_1_2_9_13_1","first-page":"457","article-title":"Loss of digitations of the hippocampal head on high\u2010resolution fast spin\u2010echo MR: a sign of mesial temporal sclerosis","volume":"19","author":"Oppenheim C","year":"1998","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550160019010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2004.12.010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688639508405161"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.17.1.59"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.12.2.303"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1997.0931"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2004.06.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.12.1895"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.02.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.020248"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000174440.31387.65"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050484"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00810.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2017.04.036"},{"key":"e_1_2_9_28_1","volume-title":"California Verbal Learning Test\u2014second edition. 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