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This study aimed to elucidate the long\u2010term prognosis of TEA regarding seizure control, memory, medical comorbidities, and life expectancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Up\u2010to\u2010date clinical information was collected for 47 people diagnosed with TEA who had joined the The Impairment of Memory in Epilepsy (TIME) study 10\u00a0years earlier. At entry to the study, information about comorbid conditions was systematically collected. Details regarding subsequent diagnoses, seizure activity, changes to treatment, or reports of cognitive impairment were obtained through the family doctor. The variables of interest were compared with UK population data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mortality in the cohort was 21 of 47 (45%), with an average age at death of 82.5\u00a0years. Seizures remained well controlled for the majority but medications required adjustments in dose and type for some (28%). A small number (three cases) remained seizure\u2010free without medication. History of cardiovascular disorders was frequent (78.7%), typically involving hypertension (55.3%). Autoimmune disorders (25.5%), cancer (23.4%), and depression (21.3%) were also commonly reported. Although persisting memory problems were often noted, dementia was diagnosed in seven cases (14.9%). Life expectancy and comorbidities in TEA did not differ from available population norms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Results suggest that life expectancy is not reduced in TEA. Although TEA does not appear to be a self\u2010limiting form of epilepsy, seizures are typically well controlled via medication. Because adjustments to medication may be required, even after long periods of stability, ongoing medical monitoring is recommended. Comorbid vascular disorders are frequent but appear similar to general population estimates. Monitoring mood may be important, given that people with chronic conditions are often vulnerable to depression. Because of persisting memory difficulties, the development of effective memory interventions for people with TEA is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17214","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T07:57:14Z","timestamp":1646639834000},"page":"1115-1129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical outcomes in transient epileptic amnesia: A 10\u2010year follow\u2010up cohort study of 47 cases"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6477-5222","authenticated-orcid":false,"given":"Sharon A.","family":"Savage","sequence":"first","affiliation":[{"name":"Cognitive &amp; Behavioural Neurology College House University of Exeter Medical School  Exeter UK"},{"name":"School of Psychological Sciences University of Newcastle  Callaghan New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Baker","sequence":"additional","affiliation":[{"name":"Cognitive &amp; 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