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We aimed to identify profiles of distinct FDS subtypes by cluster analysis of a multidimensional dataset without any a priori hypothesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an exploratory, prospective multicenter study of 169 patients with FDS. We collected biographical, trauma (childhood and adulthood traumatic experiences), semiological (seizure characteristics), and psychopathological data (psychiatric comorbidities, dissociation, and alexithymia) through psychiatric interviews and standardized scales. Clusters were identified by the Partitioning Around Medoids method. The similarity of patients was computed using Gower distance. The clusters were compared using analysis of variance, chi\u2010squared, or Fisher exact tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three patient clusters were identified in this exploratory, hypothesis\u2010generating study and named on the basis of their most prominent characteristics:\n<jats:list>\n<jats:list-item><jats:p>A \u201cNo\/Single Trauma\u201d group (31.4%), with more male patients, intellectual disabilities, and nonhyperkinetic seizures, and a low level of psychopathology;<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A \u201cCumulative Lifetime Traumas\u201d group (42.6%), with clear female predominance, hyperkinetic seizures, relatively common comorbid epilepsy, and a high level of psychopathology; and<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A \u201cChildhood Traumas\u201d group (26%), commonly with comorbid epilepsy, history of childhood sexual abuse (75%), and posttraumatic stress disorder, but also with a high level of anxiety and dissociation.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Although our cluster analysis was undertaken without any a priori hypothesis, the nature of the trauma history emerged as the most important differentiator between three common FDS disorder subtypes. This subdifferentiation of FDS disorders may facilitate the development of more specific therapeutic programs for each patient profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17230","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T13:35:22Z","timestamp":1647696922000},"page":"1500-1515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Heterogeneity of patients with functional\/dissociative seizures: Three multidimensional profiles"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7665-3310","authenticated-orcid":false,"given":"Coraline","family":"Hingray","sequence":"first","affiliation":[{"name":"Department of Neurology Nancy Regional University Hospital Center  Nancy France"},{"name":"National Center for Scientific Research Research Center for Automatic Control Mixed Unit of Research 7039 University of Lorraine  Nancy 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