{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:49:15Z","timestamp":1790718555440,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationship between posttraumatic stress disorder (PTSD) and focal epilepsy is poorly understood. It has been hypothesized that there is a complex and reciprocal potential reinforcement of the symptoms of each condition. In this study, we investigated whether there are PTSD\u2010specific brain changes in temporal lobe epilepsy (TLE). Brain fluorodeoxyglucose positron emission tomography (PET) metabolism was compared between controls and two groups of TLE patients: one group of 15 patients fulfilling the criteria for a potential diagnosis of PTSD (TLE\u2010PTSD+), another group of 24 patients without a diagnosis of PTSD (TLE\u2010PTSD\u2010), and a group of 30 healthy control participants. We compared the differences in brain PET metabolism among these three groups, and we studied their correlations with interictal and peri\u2010ictal scales of PTSD symptoms. TLE\u2010PTSD+ patients showed more significant hypometabolism involving right temporal and right orbitofrontal cortex in comparison to TLE\u2010PTSD\u2010 patients and healthy subjects. Moreover, degree of reduced metabolism in these brain areas correlated with interictal and peri\u2010ictal PTSD questionnaire scores. PTSD in temporal epilepsy is associated with specific changes in neural networks, affecting limbic and paralimbic structures. This illustrates the close intertwining of epileptogenic and psychogenic processes in these patients.<\/jats:p>","DOI":"10.1111\/epi.17300","type":"journal-article","created":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T08:18:00Z","timestamp":1652602680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Correlation between fluorodeoxyglucose positron emission tomography brain hypometabolism and posttraumatic stress disorder symptoms in temporal lobe epilepsy"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9689-4920","authenticated-orcid":false,"given":"Lisa\u2010Dounia","family":"Soncin","sequence":"first","affiliation":[{"name":"LAPCOS C\u00f4te d'Azur University  Nice France"},{"name":"Aix Marseille Univ, Inserm Institut de Neurosciences des Syst\u00e9mes  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvane","family":"Faure","sequence":"additional","affiliation":[{"name":"LAPCOS C\u00f4te d'Azur University  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-5318","authenticated-orcid":false,"given":"Aileen","family":"McGonigal","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, Inserm Institut de Neurosciences des Syst\u00e9mes  Marseille France"},{"name":"Department of Epileptology and Cerebral Rhythmology Assistance Publique H\u00f4pitaux de Marseille  Marseille France"},{"name":"Queensland Brain Institute University of Queensland and Mater Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Assistance Publique H\u00f4pitaux de Marseille  Marseille 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