{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:55:19Z","timestamp":1792194919567,"version":"4.4.0"},"reference-count":106,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ongoing challenges in diagnosing focal cortical dysplasia (FCD) mandate continuous research and consensus agreement to improve disease definition and classification. An International League Against Epilepsy (ILAE) Task Force (TF) reviewed the FCD classification of 2011 to identify existing gaps and provide a timely update. The following methodology was applied to achieve this goal: a survey of published literature indexed with ((Focal Cortical Dysplasia) AND (epilepsy)) between 01\/01\/2012 and 06\/30\/2021 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20091349) in PubMed identified the knowledge gained since 2012 and new developments in the field. An online survey consulted the ILAE community about the current use of the FCD classification scheme with 367 people answering. The TF performed an iterative clinico\u2010pathological and genetic agreement study to objectively measure the diagnostic gap in blood\/brain samples from 22 patients suspicious for FCD and submitted to epilepsy surgery. The literature confirmed new molecular\u2010genetic characterizations involving the mechanistic Target Of Rapamycin (mTOR) pathway in FCD type II (FCDII), and\n                    <jats:italic>SLC35A2<\/jats:italic>\n                    in mild malformations of cortical development (mMCDs) with oligodendroglial hyperplasia (MOGHE). The electro\u2010clinical\u2010imaging phenotypes and surgical outcomes were better defined and validated for FCDII. Little new information was acquired on clinical, histopathological, or genetic characteristics of FCD type I (FCDI) and FCD type III (FCDIII). The survey identified mMCDs, FCDI, and genetic characterization as fields for improvement in an updated classification. Our iterative clinico\u2010pathological and genetic agreement study confirmed the importance of immunohistochemical staining, neuroimaging, and genetic tests to improve the diagnostic yield. The TF proposes to include mMCDs, MOGHE, and \u201cno definite FCD on histopathology\u201d as new categories in the updated FCD classification. The histopathological classification can be further augmented by advanced neuroimaging and genetic studies to comprehensively diagnose FCD subtypes; these different levels should then be integrated into a multi\u2010layered diagnostic scheme. This update may help to foster multidisciplinary efforts toward a better understanding of FCD and the development of novel targeted treatment options.\n                  <\/jats:p>","DOI":"10.1111\/epi.17301","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:30:15Z","timestamp":1655339415000},"page":"1899-1919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":377,"title":["The\n                    <scp>ILAE<\/scp>\n                    consensus classification of focal cortical dysplasia: An update proposed by an ad hoc task force of the\n                    <scp>ILAE<\/scp>\n                    diagnostic methods commission"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5192-2089","authenticated-orcid":false,"given":"Imad","family":"Najm","sequence":"first","affiliation":[{"name":"Charles Shor Epilepsy Center, Neurological Institute  Cleveland Ohio 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