{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:25:15Z","timestamp":1771637115415,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K16888"],"award-info":[{"award-number":["19K16888"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K15721"],"award-info":[{"award-number":["22K15721"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016289","name":"Taiju Life Social Welfare Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Motivated by the challenges raised by diagnosing poststroke epilepsy (PSE), especially in nonmotor onset seizure (non\u2010MOS), we aimed to investigate the features of non\u2010MOS, including seizure sequences, patient characteristics, and electrophysiological and imaging findings in PSE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational cohort study enrolled patients with PSE whose seizure onset was witnessed. According to the International League Against Epilepsy (ILAE) 2017 seizure classification, we classified seizure\u2010onset symptoms into the non\u2010MOS and MOS groups. We compared the different clinical characteristics between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2011 and 2018, we enrolled 225 patients with PSE (median age, 75\u2009years), consisting of 97 (43%) with non\u2010MOS and 128 (57%) with MOS. Overall, 65 (67%) of the patients without MOS had no subsequent convulsions. Multivariable logistic regression analysis showed significant associations of non\u2010MOS with absence of poststroke hemiparesis (adjusted odds ratio [OR], 1.88; 95% confidence interval [CI], 1.03\u20133.42), frontal stroke lobe lesions (OR, 2.11; 95% CI, 1.14\u20133.91), and putaminal stroke lesions (OR, 2.51; 95% CI, 1.22\u20135.18) as negative indicators. Postictal single\u2010photon emission computed tomography (SPECT) detected prolonged hyperperfusion in the temporal lobe more frequently in the non\u2010MOS than in the MOS group (48% vs 31%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). The detection rate was higher than spikes\/sharp waves in scalp electroencephalography, both in the non\u2010MOS group (72% vs 33%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and the MOS group (68% vs 29%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study provides the clinical features of non\u2010MOS in patients with PSE. Compared with the patients with MOS, patients with non\u2010MOS showed less likely subsequent convulsive seizures, highlighting the clinical challenges. Postictal perfusion imaging and negative indicators of the non\u2010MOS type may help diagnose and stratify PSE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17308","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T11:19:38Z","timestamp":1653045578000},"page":"2068-2080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and imaging features of nonmotor onset seizure in poststroke epilepsy"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8117-8916","authenticated-orcid":false,"given":"Kazuki","family":"Fukuma","sequence":"first","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6023-236X","authenticated-orcid":false,"given":"Tomotaka","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naruhiko","family":"Kamogawa","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0071-7338","authenticated-orcid":false,"given":"Hiroyuki","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka 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