{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:43:38Z","timestamp":1768535018903,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sudden unexpected death in epilepsy (SUDEP) is a leading epilepsy\u2010related cause of death. Researchers have highlighted the similarities between SUDEP and sudden infant death syndrome (SIDS), but perinatal risk factors such as those identified for SIDS have not been assessed previously for SUDEP. We conducted a population\u2010based case\u2010control study of 58 SUDEP individuals and 384 living epilepsy controls born after 1982, utilizing the Swedish Medical Birth Register together with other national health registers and individual medical records to examine if prenatal and perinatal factors are associated with SUDEP risk. We observed a 3\u2010fold SUDEP risk increase for infants who were small for gestational age (SGA) (odds ratio [OR] 3.13; 95%\u00a0confidence interval [CI] 1.05\u20139.30) and for those with an Apgar score of 0\u20136 compared to 9\u201310 at 10\u2009min (OR 3.22; 95%\u00a0CI 1.05\u20139.87). After adjusting for a number of known SUDEP risk factors, we observed that the Apgar score between 0 and 6 after 10\u2009min had a 10\u2010fold increased risk for SUDEP OR 10.37 (95%\u00a0CI 1.49\u201372.01) and over a 2\u2010fold risk for those born after the 40th gestational week (OR 2.42; 95%\u00a0CI 1.03\u20135.65). The potential mechanisms linking low Apgar score, gestational age, and SGA to SUDEP risk remain to be explored.<\/jats:p>","DOI":"10.1111\/epi.17354","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T07:09:09Z","timestamp":1656745749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Perinatal risk factors for SUDEP: A population\u2010based case\u2010control study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-2935","authenticated-orcid":false,"given":"Olafur","family":"Sveinsson","sequence":"first","affiliation":[{"name":"Department of Neurology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"University Iceland Faculty of Medicine  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Andersson","sequence":"additional","affiliation":[{"name":"Center for Occupational and Environmental Medicine Stockholm County Council  Stockholm Sweden"},{"name":"Institute of Environmental Medicine, Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Center for Occupational and Environmental Medicine Stockholm County Council  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-5352","authenticated-orcid":false,"given":"Torbj\u00f6rn","family":"Tomson","sequence":"additional","affiliation":[{"name":"Department of Neurology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12666"},{"key":"e_1_2_8_3_1","first-page":"1075","article-title":"Sudden unexpected death in epilepsy","volume":"31","author":"Friedman D","year":"2022","journal-title":"Curr Opin 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and SUDEP risk: a nationwide population\u2010based case\u2010control study","volume":"10","author":"Sveinsson 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