{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:06:09Z","timestamp":1790661969909,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP17K09802"],"award-info":[{"award-number":["JP17K09802"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The mechanisms underlying accelerated long\u2010term forgetting (ALF) in patients with epilepsy are still under investigation. We examined the contribution of hippocampal subfields and their morphology to long\u2010term memory performance in patients with focal epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively assessed long\u2010term memory and performed magnetic resonance imaging in 80 patients with focal epilepsy (61 with temporal lobe epilepsy and 19 with extratemporal lobe epilepsy) and 30 healthy controls. The patients also underwent electroencephalography recording. Verbal and visuospatial memory was tested 30\u2009s, 10\u00a0min, and 1\u00a0week after learning. We assessed the volumes of the whole hippocampus and seven subfields and deformation of the hippocampal shape. The contributions of the hippocampal volumes and shape deformation to long\u2010term forgetting, controlling for confounding factors, including the presence of interictal epileptiform discharges, were assessed by multiple regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with focal epilepsy had lower intelligence quotients and route recall scores at 10\u00a0min than controls. The focal epilepsy group had smaller volumes of both the right and left hippocampal tails than the control group, but there were no statistically significant group differences for the volumes of the whole hippocampus or other hippocampal subfields. Multiple regression analyses showed a significant association between the left CA1 volume and the 1\u2010week story retention (\u03b2\u00a0=\u00a07.76; Bonferroni\u2010corrected\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.044), but this was not found for the whole hippocampus or other subfield volumes. Hippocampal shape analyses revealed that atrophy of the superior\u2010lateral, superior\u2010central, and inferior\u2010medial regions of the left hippocampus, corresponding to CA1 and CA2\/3, was associated with the verbal retention rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Our results suggest that atrophy of the hippocampal CA1 region and its associated structures disrupts long\u2010term memory consolidation in focal epilepsy. Neuronal cell loss in specific hippocampal subfields could be a key underlying cause of ALF in patients with epilepsy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.17378","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T04:35:06Z","timestamp":1658896506000},"page":"2623-2636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Atrophy of the hippocampal\n                    <scp>CA1<\/scp>\n                    subfield relates to long\u2010term forgetting in focal epilepsy"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4091-5988","authenticated-orcid":false,"given":"Takahiko","family":"Mukaino","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-4602","authenticated-orcid":false,"given":"Taira","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine International University of Health and Welfare  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yokohama","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Okadome","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsu","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Fukuoka Sanno Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei\u2010ichiro","family":"Takase","sequence":"additional","affiliation":[{"name":"Department of Neurology Iizuka Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Togao","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences Kyushu University  Fukuoka 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