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In this study, we aimed to identify and compare features of neural excitability and dynamics across multiple zebrafish seizure and epilepsy models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Inspired by video\u2010electroencephalographic recordings in patients, we developed a framework to study spontaneous and photically evoked neural and locomotor activity in zebrafish larvae, by combining high\u2010throughput behavioral tracking and whole\u2010brain in vivo two\u2010photon calcium imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our setup allowed us to dissect behavioral and physiological features that are divergent or convergent across multiple models. We observed that spontaneous locomotor and neural activity exhibit great diversity across models. Nonetheless, during photic stimulation, hyperexcitability and rapid response dynamics were well conserved across multiple models, highlighting the reliability of photically evoked activity for high\u2010throughput assays. Intriguingly, in several models, we observed that the initial elevated photic response is often followed by rapid decay of neural activity and a prominent depressed state. Elevated photic response and following depressed state in seizure\u2010prone networks are significantly reduced by the antiseizure medication valproic acid. Finally, rapid decay and depression of neural activity following photic stimulation temporally overlap with slow recruitment of astroglial calcium signals that are enhanced in seizure\u2010prone networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>We argue that fast decay of neural activity and depressed states following photic response are likely due to homeostatic mechanisms triggered by excessive neural activity. An improved understanding of the interplay between elevated and depressed excitability states might suggest tailored epilepsy therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.17380","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T05:09:11Z","timestamp":1659071351000},"page":"2543-2560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4258-8028","authenticated-orcid":false,"given":"Sverre","family":"Myren\u2010Svelstad","sequence":"first","affiliation":[{"name":"Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Neurology and Clinical Neurophysiology St Olav's University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1929-0779","authenticated-orcid":false,"given":"Ahmed","family":"Jamali","sequence":"additional","affiliation":[{"name":"Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Neurology and Clinical Neurophysiology St Olav's University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2889-9682","authenticated-orcid":false,"given":"Sunniva S.","family":"Ophus","sequence":"additional","affiliation":[{"name":"Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7145-0557","authenticated-orcid":false,"given":"Percival P.","family":"D'gama","sequence":"additional","affiliation":[{"name":"Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8344-4528","authenticated-orcid":false,"given":"Anna M.","family":"Ostenrath","sequence":"additional","affiliation":[{"name":"Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1318-6425","authenticated-orcid":false,"given":"Aytac Kadir","family":"Mutlu","sequence":"additional","affiliation":[{"name":"Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4526-9807","authenticated-orcid":false,"given":"Helene Homme","family":"Hoffshagen","sequence":"additional","affiliation":[{"name":"Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1992-7829","authenticated-orcid":false,"given":"Adriana L.","family":"Hotz","sequence":"additional","affiliation":[{"name":"Department of Molecular Life Sciences University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-480X","authenticated-orcid":false,"given":"Stephan C. 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