{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:50:13Z","timestamp":1791823813097,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG\u2010055328"],"award-info":[{"award-number":["AG\u2010055328"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS\u2010106983"],"award-info":[{"award-number":["NS\u2010106983"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004866","name":"New York State Office of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To test the hypothesis that high\u2010frequency oscillations (HFOs) between 250 and 500\u2009Hz occur in mouse models of Alzheimer's disease (AD) and thus are not unique to epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Experiments were conducted in three mouse models of AD: Tg2576 mice that simulate a form of familial AD, presenilin 2 knock\u2010out (PS2KO) mice, and the Ts65Dn model of Down's syndrome. We recorded HFOs using wideband (0.1\u2013500\u2009Hz, 2\u00a0kHz) intra\u2010hippocampal and cortical surface electroencephalography (EEG) at 1\u00a0month until 24\u2009months of age during wakefulness, slow wave sleep (SWS), and rapid eye movement (REM) sleep. In addition, interictal spikes (IISs) and seizures were analyzed for the possible presence of HFOs. Comparisons were made to the intra\u2010hippocampal kainic acid and pilocarpine models of epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We describe for the first time that hippocampal and cortical HFOs are a new EEG abnormality in AD mouse models. HFOs occurred in all transgenic mice but no controls. They were also detectable as early as 1\u00a0month of age and prior to amyloid beta plaque neuropathology. HFOs were most frequent during SWS (vs REM sleep or wakefulness). Notably, HFOs in the AD and epilepsy models were indistinguishable in both spectral frequency and duration. HFOs also occurred during IISs and seizures in the AD models, although with altered spectral properties compared to isolated HFOs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Our data demonstrate that HFOs, an epilepsy biomarker with high translational value, are not unique to epilepsy and thus not disease specific. Our findings also strengthen the idea of hyperexcitability in AD and its significant overlap with epilepsy. HFOs in AD mouse models may serve as an EEG biomarker, which is detectable from the scalp and thus amenable to noninvasive detection in people at risk for AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.17462","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T08:34:13Z","timestamp":1667896453000},"page":"231-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["High\u2010frequency oscillations (\n                    <scp>250\u2013500\u2009Hz<\/scp>\n                    ) in animal models of Alzheimer's disease and two animal models of epilepsy"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-5993","authenticated-orcid":false,"given":"Christos Panagiotis","family":"Lisgaras","sequence":"first","affiliation":[{"name":"Departments of Child &amp; Adolescent Psychiatry, Neuroscience &amp; Physiology, and Psychiatry, and the Neuroscience Institute New York University Langone Health  New York New York USA"},{"name":"Center for Dementia Research, The Nathan Kline Institute for Psychiatric Research New York State Office of Mental Health  Orangeburg New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-3383","authenticated-orcid":false,"given":"Helen E.","family":"Scharfman","sequence":"additional","affiliation":[{"name":"Departments of Child &amp; Adolescent Psychiatry, Neuroscience &amp; Physiology, and Psychiatry, and the Neuroscience Institute New York University Langone Health  New York New York USA"},{"name":"Center for Dementia Research, The Nathan Kline Institute for Psychiatric Research New York State Office of Mental Health  Orangeburg New York 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