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The contribution of demographic and clinical variables to cognitive performance was evaluated. A sensitivity analysis was conducted by examining the base rates of impairment across several impairment thresholds. The IC\u2010CoDE taxonomy was then applied, and the base rate of cognitive phenotypes for each cutoff was calculated. The distribution of phenotypes was compared to the published IC\u2010CoDE taxonomy data, which utilized a large, multicenter cohort of English\u2010speaking patients with TLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across the different impairment cutoffs, memory was the most impaired cognitive domain, with impairments in list learning ranging from 50% to 78%. Application of the IC\u2010CoDE taxonomy utilizing a \u22121.5\u2010SD cutoff revealed an intact cognitive profile in 47.6% of patients, single\u2010domain impairment in 23.8% of patients, bidomain impairment in 14.3% of patients, and generalized impairment in 14.3% of the sample. This distribution was comparable to the phenotype distribution observed in the IC\u2010CoDE validation sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We demonstrate a similar pattern and distribution of cognitive phenotypes in a Spanish\u2010speaking epilepsy cohort compared to an English\u2010speaking sample. This suggests stability in the underlying phenotypes associated with TLE and applicability of the IC\u2010CoDE for guiding cognitive diagnostics in epilepsy research that can be applied to culturally and linguistically diverse samples.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17501","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T11:59:31Z","timestamp":1673351971000},"page":"728-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Establishing the cross\u2010cultural applicability of a harmonized approach to cognitive diagnostics in epilepsy: Initial results of the International Classification of Cognitive Disorders in Epilepsy in a Spanish\u2010speaking sample"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-6990","authenticated-orcid":false,"given":"Anny","family":"Reyes","sequence":"first","affiliation":[{"name":"Center for 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