{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:51:40Z","timestamp":1762660300563,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801740","91859207"],"award-info":[{"award-number":["81801740","91859207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M723561"],"award-info":[{"award-number":["2022M723561"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypothalamic hamartomas (HHs) are uncommon benign lesions of neuronal and glial cells in the inferior hypothalamus. They have been linked to epilepsy, premature puberty, and cognitive and behavioral impairment. We report a 13\u2010year\u2010old patient who was referred to a multidisciplinary treatment team for epilepsy with 6 months of convulsive seizures. Sustained seizure control was not achieved despite the use of multiple antiepileptic agents. He had been plagued by unexplained paroxysmal bursts of laughter for &gt;11\u2009years. Video\u2010electroencephalography showed diffuse epileptic discharges prominent in the right hemisphere in both interictal and ictal phases. Magnetic resonance imaging demonstrated an isointense gray matter mass on the right lateral walls of the third ventricle, with focal hypometabolism on <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography (PET). The patient subsequently was enrolled in a clinical trial of <jats:sup>18<\/jats:sup>F\u2010SynVesT\u20101 PET in epilepsy, and an increased <jats:sup>18<\/jats:sup>F\u2010SynVesT\u20101 uptake was noted in the mass. After excluding hormonal abnormalities, the patient underwent open resection targeting HHs. We used <jats:sup>18<\/jats:sup>F\u2010SynVesT\u20101 as a specific PET tracer for synaptic vesicle glycoprotein 2A, which is ubiquitously expressed in brain synapses. <jats:sup>18<\/jats:sup>F\u2010SynVesT\u20101 PET may hold promise as a supplementary tool in the presurgical localization and evaluation of HHs.<\/jats:p>","DOI":"10.1111\/epi.17533","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T15:08:50Z","timestamp":1675696130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp><sup>18<\/sup>F\u2010SynVesT<\/scp>\u20101 <scp>positron emission tomography<\/scp> in a hypothalamic hamartoma with abnormal uptake"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-4000","authenticated-orcid":false,"given":"Ling","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital, Central South 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Changsha China"},{"name":"National Clinical Research Center for Geriatric Diseases Xiangya Hospital, Central South University  Changsha 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