{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:14:43Z","timestamp":1790745283400,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202006070175"],"award-info":[{"award-number":["202006070175"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1F1A1052303"],"award-info":[{"award-number":["2021R1F1A1052303"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010446","name":"Institute for Basic Science","doi-asserted-by":"publisher","award":["IBS\u2010R015\u2010D1"],"award-info":[{"award-number":["IBS\u2010R015\u2010D1"]}],"id":[{"id":"10.13039\/501100010446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults. Here we profiled local neural function in TLE\n                      <jats:italic>in vivo<\/jats:italic>\n                      , building on prior evidence that has identified widespread structural alterations. Using resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI), we mapped the whole\u2010brain intrinsic neural timescales (INT), which reflect temporal hierarchies of neural processing. Parallel analysis of structural and diffusion MRI data examined associations with TLE\u2010related structural compromise. Finally, we evaluated the clinical utility of INT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 46 patients with TLE and 44 healthy controls from two independent sites, and mapped INT changes in patients relative to controls across hippocampal, subcortical, and neocortical regions. We examined region\u2010specific associations to structural alterations and explored the effects of age and epilepsy duration. Supervised machine learning assessed the utility of INT for identifying patients with TLE vs controls and left\u2010 vs right\u2010sided seizure onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Relative to controls, TLE showed marked INT reductions across multiple regions bilaterally, indexing faster changing resting activity, with strongest effects in the ipsilateral medial and lateral temporal regions, and bilateral sensorimotor cortices as well as thalamus and hippocampus. Findings were similar, albeit with reduced effect sizes, when correcting for structural alterations. INT reductions in TLE increased with advancing disease duration, yet findings differed from the aging effects seen in controls. INT\u2010derived classifiers discriminated patients vs controls (balanced accuracy, 5\u2010fold: 76%\u2009\u00b1\u20092.65%; cross\u2010site, 72%\u201383%) and lateralized the focus in TLE (balanced accuracy, 5\u2010fold: 96%\u2009\u00b1\u20092.10%; cross\u2010site, 95%\u201397%), with high accuracy and cross\u2010site generalizability. Findings were consistent across both acquisition sites and robust when controlling for motion and several methodological confounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Our findings demonstrate atypical macroscale function in TLE in a topography that extends beyond mesiotemporal epicenters. INT measurements can assist in TLE diagnosis, seizure focus lateralization, and monitoring of disease progression, which emphasizes promising clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.17541","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T20:06:06Z","timestamp":1676059566000},"page":"998-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Atypical intrinsic neural timescales in temporal lobe epilepsy"],"prefix":"10.1111","volume":"64","author":[{"given":"Ke","family":"Xie","sequence":"first","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-8998","authenticated-orcid":false,"given":"Jessica","family":"Royer","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5701-1307","authenticated-orcid":false,"given":"Sara","family":"Lariviere","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Rodriguez\u2010Cruces","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinder Vos","family":"de Wael","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010yong","family":"Park","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"},{"name":"Department of Data Science Inha University  Incheon Republic of Korea"},{"name":"Center for Neuroscience Imaging Research Institute for Basic Science  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Auer","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahin","family":"Tavakol","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"DeKraker","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chifaou","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Analytical Neurophysiology Laboratory, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Caciagli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani S.","family":"Bassett","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Physics and Astronomy University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Electrical and Systems Engineering University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Neurology University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Psychiatry University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-5703","authenticated-orcid":false,"given":"Andrea","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8947-9518","authenticated-orcid":false,"given":"Neda","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-1529","authenticated-orcid":false,"given":"Birgit","family":"Frauscher","sequence":"additional","affiliation":[{"name":"Analytical Neurophysiology Laboratory, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7842-3869","authenticated-orcid":false,"given":"Luis","family":"Concha","sequence":"additional","affiliation":[{"name":"Brain Connectivity Laboratory, Institute of Neurobiology Universidad Nacional Aut\u00f3noma de Mexico (UNAM)  Juriquilla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9256-6041","authenticated-orcid":false,"given":"Boris C.","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx341"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa200"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc6457"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2966112"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-11-66"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24691"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25763"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16540"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16759"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15908-3"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006436118"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42256"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61277"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2021.11.007"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003383117"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117141"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2110274119"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-0958-5"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17032"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2020.01.008"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01682-y"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116706"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg034"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119612"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56151"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e0f80a"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(09)70882-1"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww167"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.048"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-0794-7"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117038"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31730-5"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01186-4"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1145\/1961189.1961199"},{"key":"e_1_2_11_36_1","doi-asserted-by":"crossref","unstructured":"ShinnM HuA TurnerL NobleS PrellerKH JiJL et al.Spatial and temporal autocorrelation weave complexity in brain networks.bioRxiv.2022.","DOI":"10.1101\/2021.06.01.446561"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.50482"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12066"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1911461117"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16864"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00073-X"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa7095"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1708"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.12.007"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa397"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww187"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25037"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102765"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3171\/2022.1.JNS212031"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.17541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.17541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.17541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:35:39Z","timestamp":1692718539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.17541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/epi.17541"],"URL":"https:\/\/doi.org\/10.1111\/epi.17541","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.07.01.498416","asserted-by":"object"}]},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"2022-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}