{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:16:04Z","timestamp":1787901364108,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["5 x mille"],"award-info":[{"award-number":["5 x mille"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Large aperiodic bursts of activations named neuronal avalanches have been used to characterize whole\u2010brain activity, as their presence typically relates to optimal dynamics. Epilepsy is characterized by alterations in large\u2010scale brain network dynamics. Here we exploited neuronal avalanches to characterize differences in electroencephalography (EEG) basal activity, free from seizures and\/or interictal spikes, between patients with temporal lobe epilepsy (TLE) and matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      We defined neuronal avalanches as starting when the\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scored source\u2010reconstructed EEG signals crossed a specific threshold in any region and ending when all regions returned to baseline. This technique avoids data manipulation or assumptions of signal stationarity, focusing on the aperiodic, scale\u2010free components of the signals. We computed individual avalanche transition matrices to track the probability of avalanche spreading across any two regions, compared them between patients and controls, and related them to memory performance in patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed a robust topography of significant edges clustering in regions functionally and structurally relevant for the TLE, such as the entorhinal cortex, the inferior parietal and fusiform area, the inferior temporal gyrus, and the anterior cingulate cortex. We detected a significant correlation between the centrality of the entorhinal cortex in the transition matrix and the long\u2010term memory performance (delay recall Rey\u2013Osterrieth Complex Figure Test).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Our results show that the propagation patterns of large\u2010scale neuronal avalanches are altered in TLE during the resting state, suggesting a potential diagnostic application in epilepsy. Furthermore, the relationship between specific patterns of propagation and memory performance support the neurophysiological relevance of neuronal avalanches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.17551","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T03:50:51Z","timestamp":1676605851000},"page":"1278-1288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Altered spreading of neuronal avalanches in temporal lobe epilepsy relates to cognitive performance: A resting\u2010state\n                    <scp>hdEEG<\/scp>\n                    study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0778-3920","authenticated-orcid":false,"given":"Gian Marco","family":"Duma","sequence":"first","affiliation":[{"name":"Epilepsy Unit IRCCS E. 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Medea Scientific Institute  Treviso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Mento","sequence":"additional","affiliation":[{"name":"Department of General Psychology University of Padova  Padova Italy"},{"name":"Padova Neuroscience Center (PNC) University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Vitale","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Neuroradiology Unit San Bortolo Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella Scotto","family":"Opipari","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Neuroradiology Unit San Bortolo Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-8860","authenticated-orcid":false,"given":"Viktor","family":"Jirsa","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-9059","authenticated-orcid":false,"given":"Paolo","family":"Bonanni","sequence":"additional","affiliation":[{"name":"Epilepsy Unit IRCCS E. Medea Scientific Institute  Treviso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-9800","authenticated-orcid":false,"given":"Pierpaolo","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences des Syst\u00e8mes Aix\u2010Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400181111"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2022.08.007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1140\/epjnbp11"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13791"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24691"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2021.106745"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11111513"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17032"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2020.00054"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4286-12.2013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67400"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83425-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201200"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0809-16.2016"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002312"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2009.06923.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2022.08.010"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100720200003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000117297"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01997792"},{"key":"e_1_2_10_22_1","volume-title":"WAIS\u2010IV. 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