{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:22:01Z","timestamp":1792462921846,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC014589"],"award-info":[{"award-number":["DC014589"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Lexical retrieval deficits are characteristic of a variety of different neurological disorders. However, the exact substrates responsible for this are not known. We studied a large cohort of patients undergoing surgery in the dominant temporal lobe for medically intractable epilepsy (<jats:italic>n<\/jats:italic>\u00a0=\u200995) to localize brain regions that were associated with anomia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a multivariate voxel\u2010based lesion\u2013symptom mapping analysis to correlate surgical lesions within the temporal lobe with changes in naming ability. Additionally, we used a surface\u2010based mixed\u2010effects multilevel analysis to estimate group\u2010level broadband gamma activity during naming across a subset of patients with electrocorticographic recordings and integrated these results with lesion\u2013deficit findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed that ventral temporal regions, centered around the middle fusiform gyrus, were significantly associated with a decline in naming. Furthermore, we found that the ventral aspect of temporal lobectomies was linearly correlated to a decline in naming, with a clinically significant decline occurring once the resection extended 6\u00a0cm from the anterior tip of the temporal lobe on the ventral surface. On electrocorticography, the majority of these cortical regions were functionally active following visual processing. These loci coincide with the sites of susceptibility artifacts during echoplanar imaging, which may explain why this region has been previously underappreciated as the locus responsible for postoperative naming deficits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Taken together, these data highlight the crucial contribution of the ventral temporal cortex in naming and its important role in the pathophysiology of anomia following temporal lobe resections. As such, surgical strategies should attempt to preserve this region to mitigate postoperative language deficits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17555","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T08:20:27Z","timestamp":1676881227000},"page":"1200-1213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Critical role of the ventral temporal lobe in naming"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0955-466X","authenticated-orcid":false,"given":"Kathryn M.","family":"Snyder","sequence":"first","affiliation":[{"name":"Vivian L. Smith Department of Neurosurgery McGovern Medical School at UT Health Houston  Houston Texas USA"},{"name":"Texas Institute for Restorative Neurotechnologies University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiefer J.","family":"Forseth","sequence":"additional","affiliation":[{"name":"Vivian L. Smith Department of Neurosurgery McGovern Medical School at UT Health Houston  Houston Texas USA"},{"name":"Texas Institute for Restorative Neurotechnologies University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-062X","authenticated-orcid":false,"given":"Cristian","family":"Donos","sequence":"additional","affiliation":[{"name":"Vivian L. Smith Department of Neurosurgery McGovern Medical School at UT Health Houston  Houston Texas USA"},{"name":"Faculty of Physics University of Bucharest  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"Rollo","sequence":"additional","affiliation":[{"name":"Vivian L. Smith Department of Neurosurgery McGovern Medical School at UT Health Houston  Houston Texas USA"},{"name":"Texas Institute for Restorative Neurotechnologies University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Fischer\u2010Baum","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Breier","sequence":"additional","affiliation":[{"name":"Vivian L. Smith Department of Neurosurgery McGovern Medical School at UT Health Houston  Houston Texas USA"},{"name":"Memorial Hermann Hospital Texas Medical Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-2365","authenticated-orcid":false,"given":"Nitin","family":"Tandon","sequence":"additional","affiliation":[{"name":"Vivian L. 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