{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:03:09Z","timestamp":1790402589264,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001260","name":"National Organization for Rare Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ketogenic diet, a high\u2010fat, low\u2010carbohydrate diet, is an established treatment for patients with severe epilepsy. We have previously reported a moderate reduction in seizure frequency after treatment with a modified Atkins diet. This study aimed to see whether dietary therapy impacts patients' health\u2010related quality of life (HRQOL). In a randomized controlled design, we compared the change in self\u2010reported HRQOL among adults with difficult\u2010to\u2010treat epilepsy after a 12\u2010week diet intervention. Thirty\u2010nine patients with drug\u2010resistant focal epilepsy (age\u00a0=\u00a016\u201365\u2009years) were randomized to eat a modified Atkins diet with maximum 16 g of carbohydrate per day (diet group,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200919) or to continue eating habitual diet (control group,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200920). No changes to the other epilepsy treatments were allowed. Patient\u2010reported HRQOL was assessed with the Quality of Life in Epilepsy Inventory\u201089 (QOLIE\u201089). The diet group experienced a statistically significant improvement in mean total score of QOLIE\u201089 of 10 points compared to controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.002). Moreover, although not statistically significant when using a cutoff of 50% seizure reduction, our data suggest an association between diet\u2010induced reduction in seizure frequency and improvement in HRQOL. The improvement in HRQOL was not associated with diet\u2010induced weight reduction.\n                  <\/jats:p>","DOI":"10.1111\/epi.17585","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T02:17:20Z","timestamp":1678933040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Health\u2010related quality of life in adults with drug\u2010resistant focal epilepsy treated with modified Atkins diet in a randomized clinical trial"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1778-0835","authenticated-orcid":false,"given":"Magnhild","family":"Kverneland","sequence":"first","affiliation":[{"name":"National Center for Epilepsy, Member of the ERN EpiCARE Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Otto","family":"Nakken","sequence":"additional","affiliation":[{"name":"National Center for Epilepsy, Member of the ERN EpiCARE Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Hofoss","sequence":"additional","affiliation":[{"name":"National Center for Epilepsy, Member of the ERN EpiCARE Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette Holth","family":"Skogan","sequence":"additional","affiliation":[{"name":"National Center for Epilepsy, Member of the ERN EpiCARE Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Ole","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Nutrition University of Oslo  Oslo Norway"},{"name":"Department of Hematology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaja Kristine","family":"Selmer","sequence":"additional","affiliation":[{"name":"National Center for Epilepsy, Member of the ERN EpiCARE Oslo University Hospital  Oslo Norway"},{"name":"Division of Clinical Neuroscience, Department of Research and Innovation Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Ingvar","family":"Lossius","sequence":"additional","affiliation":[{"name":"National Center for Epilepsy, Member of the ERN EpiCARE Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02397.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32596-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13769"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23601"},{"key":"e_1_2_11_6_1","article-title":"Ketogenic diets for drug\u2010resistant epilepsy","volume":"6","author":"Martin\u2010McGill KJ","year":"2020","journal-title":"Cochrane Database Syst 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