{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:30:37Z","timestamp":1785522637611,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Previous studies using advanced magnetic resonance imaging (MRI) techniques have documented abnormal transmantle bands connecting ectopic nodules to overlying cortex in patients with periventricular nodular heterotopia (PNH). We describe a similar finding using conventional MRI techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were identified by means of a full\u2010text search of radiological reports. All scanning was performed using conventional sequences at 3 Tesla (3T). Scans were reviewed by three neuroradiologists, and we characterized imaging features based on type of PNH and cortical irregularities associated with the transmantle band.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total 57 PNH patients were reviewed, of whom 41 demonstrated a \u201ctransmantle band\u201d connecting the nodule to the overlying cortex. One or more periventricular heterotopic nodules was present in all 41 patients\u2014this was bilateral in 29 of 41 (71%) and unilateral in the remaining 29%. In many cases there was more than one such band, and in some cases this band was nodular. In 19 of the cases, the cortex to which the band connected was abnormal, showing thinning in 4 cases, thickening in 5 cases, and polymicrogyria in another 10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The transmantle band can be seen frequently in both unilateral and bilateral cases of PNH and can be visualized with conventional 3T MRI sequences. The band highlights the underlying neuronal migration issues at play in the pathogenesis of this disorder, but its underlying role in the complex, patient\u2010specific epileptogenic networks in this cohort has yet to be determined and warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17604","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T14:33:17Z","timestamp":1680618797000},"page":"1605-1611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Periventricular nodular heterotopia associated with a \u201ctransmantle band sign\u201d in patients with epilepsy"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0916-7387","authenticated-orcid":false,"given":"Nicolin","family":"Hainc","sequence":"first","affiliation":[{"name":"Division of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital University Health Network, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Alcaide\u2010Leon","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital University Health Network, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Willinsky","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital University Health Network, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Krings","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital University Health Network, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7182-5112","authenticated-orcid":false,"given":"Patrick","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital University Health Network, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3312"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.182.2.1732969"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00374.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470000312"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl125"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000052689.03214.61"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13895"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebcr.2018.09.007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03466.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016150852"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2006.10.004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh357"},{"key":"e_1_2_10_14_1","first-page":"146","article-title":"Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models","volume":"146","author":"Buchsbaum IY","year":"2019","journal-title":"Dev Camb 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