{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:17:13Z","timestamp":1788599833131,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:00:00Z","timestamp":1685836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003769","name":"Eisai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was undertaken to evaluate perampanel (PER) when used under real\u2010world conditions to treat people with idiopathic generalized epilepsy (IGE) included in the PERaMpanel pooled analysIs of effecTiveness and tolerability (PERMIT) study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The multinational, retrospective, pooled analysis PERMIT explored the use of PER in people with focal and generalized epilepsy treated in clinical practice across 17 countries. This subgroup analysis included PERMIT participants with IGE. Time points for retention and effectiveness measurements were 3, 6, and 12\u2009months (last observation carried forward, defined as \"last visit,\" was also applied to effectiveness). Effectiveness was evaluated by seizure type (total seizures, generalized tonic\u2013clonic seizures [GTCS], myoclonic seizures, absence seizures) and included \u226550% responder rate and seizure freedom rate (defined as no seizures since at least the previous visit). Safety\/tolerability was monitored throughout PER treatment and evaluated by documenting the incidence of adverse events (AEs), including psychiatric AEs and those leading to treatment discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Full Analysis Set included 544 people with IGE (51.9% women, mean age\u2009=\u200933.3\u2009years, mean epilepsy duration\u2009=\u200918.1\u2009years). At 3, 6, and 12\u2009months, 92.4%, 85.5%, and 77.3% of participants were retained on PER treatment, respectively (Retention Population, <jats:italic>n<\/jats:italic>\u2009=\u2009497). At the last visit, responder and seizure freedom rates were, respectively, 74.2% and 54.6% (total seizures), 81.2% and 61.5% (GTCS), 85.7% and 66.0% (myoclonic seizures), and 90.5% and 81.0% (absence seizures) (Effectiveness Population, <jats:italic>n<\/jats:italic>\u2009=\u2009467). AEs occurred in 42.9% of patients and included irritability (9.6%), dizziness\/vertigo (9.2%), and somnolence (6.3%) (Tolerability Population, <jats:italic>n<\/jats:italic>\u2009=\u2009520). Treatment discontinuation due to AEs was 12.4% over 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This subgroup analysis of the PERMIT study demonstrated the effectiveness and good tolerability of PER in people with IGE when administered under everyday clinical practice conditions. These findings are in line with clinical trial evidence, supporting PER's use as broad\u2010spectrum antiseizure medication for the treatment of IGE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.17631","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T12:14:20Z","timestamp":1682684060000},"page":"2094-2107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Perampanel for the treatment of people with idiopathic generalized epilepsy in clinical practice"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-2692","authenticated-orcid":false,"given":"Eugen","family":"Trinka","sequence":"first","affiliation":[{"name":"Department of Neurology Christian\u2010Doppler University Hospital, Paracelsus Medical University, Center for Cognitive Neuroscience, Member of EpiCARE  Salzburg Austria"},{"name":"Neuroscience Institute, Christian\u2010Doppler University Hospital, Paracelsus Medical University Center for Cognitive Neuroscience  Salzburg Austria"},{"name":"Institute of Public Health, Medical Decision\u2010Making, and HTA UMIT\u2013Private University for Health Sciences, Medical Informatics, and Technology  Hall in Tyrol Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7513-5706","authenticated-orcid":false,"given":"Taoufik","family":"Alsaadi","sequence":"additional","affiliation":[{"name":"Department of Neurology American Center for Psychiatry and Neurology  Abu Dhabi United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Goji","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Department Aichi Medical University  Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketoshi","family":"Maehara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Medical and Dental University  Tokyo Japan"},{"name":"Department of Neurosurgery Tsuchiura Kyodo General Hospital  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Alberta Children's Hospital  Calgary Alberta Canada"},{"name":"University Medical Center Freiburg, Member of EpiCARE  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Renna","sequence":"additional","affiliation":[{"name":"Neurological Clinic and Stroke Unit \u201cA. 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