{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:35Z","timestamp":1787014175353,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Epilepsy is a common comorbidity of glioblastoma. Seizures may occur in various phases of the disease. We aimed to assess potential risk factors for seizures in accordance with the point in time at which they occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed medical files of adult patients with de novo glioblastoma treated at our institution between January 2006 and January 2020. We categorized seizures as preoperative seizures (POS), early postoperative seizures (EPS; before initiation of radio[chemo]therapy [RCT]), seizures during radiotherapy (SDR; during or &lt;30\u2009days after RCT), and posttherapeutic seizures (PTS; \u226530\u2009days after completion of RCT). We addressed associations between patients' characteristics and their seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the final cohort (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009520), 292 patients experienced seizures. POS, EPS, SDR, and\/or PTS occurred in 29.6% (154\/520), 6.0% (31\/520), 13.8% (70\/509), and 36.1% (152\/421) of patients, respectively. POS occurred more frequently in patients with higher Karnofsky Performance Scale scores (odds ratio [OR] =\u20093.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001) and tumor location in the temporal lobe (OR\u2009=\u20091.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.034). None of the parameters we analyzed was related to the occurrence of EPS. SDR were independently associated with tumor location (parietal lobe, OR\u2009=\u20091.86,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.027) and POS, but not EPS, and were independent of RCT. PTS were independently associated with tumor progression (OR\u2009=\u20092.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and with occurrence of SDR (OR\u2009=\u20093.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), and negatively correlated with temporal lobe location (OR = .58,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.014). In patients with tumors exclusively located in the temporal lobe, complete tumor resection was associated with a decreased risk of postoperative seizures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Seizures in glioblastoma patients have various, time\u2010dependent risk factors. Temporal lobe localization was a risk factor for preoperative seizures; surgery may have had a protective effect in these patients. RCT did not have dose\u2010dependent pro\u2010 or anticonvulsive effects. PTS were associated with tumor progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.17658","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T01:45:48Z","timestamp":1684460748000},"page":"1853-1861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Time\u2010dependent risk factors for epileptic seizures in glioblastoma patients: A retrospective analysis of 520 cases"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4888-6539","authenticated-orcid":false,"given":"Jenny","family":"Stritzelberger","sequence":"first","affiliation":[{"name":"Full member of ERN EpiCARE, Epilepsy Center, Department of Neurology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gesmann","sequence":"additional","affiliation":[{"name":"Full member of ERN EpiCARE, Epilepsy Center, Department of Neurology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imke","family":"Fuhrmann","sequence":"additional","affiliation":[{"name":"Full member of ERN EpiCARE, Epilepsy Center, Department of Neurology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Brandner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7211-3934","authenticated-orcid":false,"given":"Tamara M.","family":"Welte","sequence":"additional","affiliation":[{"name":"Full member of ERN EpiCARE, Epilepsy Center, Department of Neurology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Balk","sequence":"additional","affiliation":[{"name":"Full member of ERN EpiCARE, Epilepsy Center, Department of Neurology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Eisenhut","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnd","family":"D\u00f6rfler","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Coras","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Biometry and Epidemiology and Department of Psychosomatic Medicine and Psychotherapy Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwab","sequence":"additional","affiliation":[{"name":"Full member of ERN EpiCARE, Epilepsy Center, Department of Neurology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Putz","sequence":"additional","affiliation":[{"name":"Department of Radio\u2010Oncology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Fietkau","sequence":"additional","affiliation":[{"name":"Department of Radio\u2010Oncology Universit\u00e4tsklinikum Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t 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